Our results demonstrated that the FUT2 determines the O-glycosylation pattern of Muc5ac, with Fut2 knock-out leading to a marked decrease in α1,2-fucosylated structures and increased expression of the terminal type 1 glycan structure Lewis-a. Importantly, for the first time, we structurally ...
The significance of our current finding is that MUC5AC contains an epitope structure which is newly expressed early in the development of pancreatic neoplasia. Whether or not this epitope structure represents a reactive site for activation of oncogenesis in the pancreas is as yet unknown. ...
In gastric cancer we can observe the presence of the mucins normally expressed in the stomach, MUC1, MUC5AC, and MUC6, as well as de novo expression of the intestinal mucin MUC2 (Reis et al., 1998, 2000). The pattern of mucin expression, including the expression of the intestinal ...
Mucins are high-molecular-weight glycoproteins expressed throughout the gastrointestinal tract, with a key role in mucosal protection and function. In gastric cancer expression of MUC5AC and MUC1 is reduced and denovo expression of MUC2 occurs. ...
These data implicate MUC5AC as a specific mucin species to which PAM4 is reactive. Furthermore, this realization may allow for the improvement of the current PAM4 serum-based immunoassay for detection of early-stage PDAC by the application of anti-MUC5AC MAbs as probes in this sandwich EIA...
Depending on the class of relative mRNA expression of mucins, adenocarcinomas were classified as having a gastric (mid or high mRNA levels of MUC5AC, MUC6, and/or MUC1 and low mRNA levels of MUC2, MUC4, and MUC13), intestinal (low mRNA levels of gastric mucins and high mRNA levels of...
Since AHR in allergic mouse lungs was dependent on a combination of ASM contraction and Muc5ac secretion (Figs 2–4), and since changes in airway structure and function did not fit models of homogenous changes in airflow, these findings further support the hypothesis that epithelial Muc5ac ...
The primary goal is to unveil signaling pathways altered by asbestos that regulate the expression of hClcal/mclcaS and muc5ac, two genes involved in mucin production and/or secretion. This hypothesis will be tested in three specific aims which encompass both in vivo and in vitro approaches to...
[8]. Terminal residues such as sulfate and Neu5Ac are essential in the enhanced mucus viscosity and structural integrity of the mucus layer [73], as the removal of terminal Neu5Ac is an initial step in the sequential degradation of mucin glycans [74]. Certain bacteria, known as mucin-...
P. TNF-alpha in the regulation of MUC5AC secretion: some aspects of cytokine-induced mucin hypersecretion on the in vitro model. Cytokine 12, 1732–1736 (2000). Article CAS PubMed Google Scholar Enss, M. L. et al. Proinflammatory cytokines trigger MUC gene expression and mucin release ...