Mucosal immunity mediated by antibody-mucin cross-linkingArthi KannanYing-Ying WangDurai SubramaniMichael MurphyKenetta NunnThomas MoenchRichard ConeSamuel LaiGlycobiology
1). MUC3A/B, MUC4, MUC11/12, MUC16, and MUC17, are part of large human MAMs found at the apex of epithelial cells of the secretory mucosa (Desseyn et al., 2008) and may to a lower extent contribute to the mucus gel. Several small MAMs are nonspecific to secretory mucosal tissues...
et al. Role of ABO secretor status in mucosal innate immunity and H. pylori infection. PLoS Pathog. 4, e2 (2008). Article CAS PubMed PubMed Central Google Scholar Cooke, C. L. et al. Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with ...
Depending on the class of relative mRNA expression of mucins, adenocarcinomas were classified as having a gastric (mid or high mRNA levels of MUC5AC, MUC6, and/or MUC1 and low mRNA levels of MUC2, MUC4, and MUC13), intestinal (low mRNA levels of gastric mucins and high mRNA levels of...
Mucosal Immunology Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13 Nature: 201082a European Journal of Pharmacology Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathw...
AOE is a fungal allergen pertinent to human asthma that upon mucosal sensitization elicits strong asthma-like responses in mice38. In WT animals, AOE challenge caused AHR to MCh, but in both Muc5ac À / À lines, AHR was abolished (Fig. 2b,c; Supplementary Fig. 1b). Importantly, ...
Because TNF-α can up-regulate the levels of mucus protein (MUC5AC) in airway epithe- lial cells dependent on Nuclear factor kappa-B (NF-κB) activation, we explored the role of the NF-κB signalling pathway in TNF-α induced MUC1 expression during RSV infection [15, 16]. Because the...
In this study, piglets were weaned early from their sows at 21 days of age. Eight piglets (28 days old) with active diarrhea were selected from 6 l. Gender-matched littermates were used as the healthy controls. The overall structure of mucosal and luminal microbiota in the colon investigate...
Next, we investigated the molecular mechanism by which GSDME regulates the resistance to digestive enzymes. The mucosal epithelium can protect itself by expressing a layer of mucous molecules to retain particles and exogenous enzymes, which prompted us to hypothesize that GSDME promotes resistance to di...
Cells from the surface foveolar epithelium express both the secreted MUC5AC and the membrane-bound MUC1, being the latter also found in the neck gland cells (Figure 1aI). As for the deeper layers of the gastric mucosa, MUC6 is secreted by the neck glandular cells (Figure 1aII). ...