Mucin 5AC抗体[克隆45M1] 英文名字 Mucin 5AC Antibody [Clone 45M1] 供应商 Abgent 产品货号 A-AH10041 产品报价 ￥2870/100 ug 产品说明书 点击查看 购买方式 产品新闻 背景资料 This MAb recognizes the peptide core of gastric mucin M1 (>1,000kDa) (recently identified as Mucin 5AC). Its epitope...
1.Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes. 2.Mucins in cancer: function, prognosis and therapy. 3.Cancer-associated mucins: role in immune modulation and metastasis.
This antibody to gastric mucin M1 reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous and cancerous colon, but it does not react with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin r...
MUC5AC (Mucin 5AC) Mouse Monoclonal IgG Antibody. Immunohistochemistry (IHC) applications. Human specificity
Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either...
Immunohistochemical Study of the Expression of MUC6 Mucin and Co-expression of Other Secreted Mucins (MUC5AC and MUC2) in Human Gastric Carcinomas To investigate the expression of MUC6 mucin in gastric carcinomas, we generated a novel monoclonal antibody (MAb CLH5) using an MUC6 synthetic ...
Here, we report the impact of MUC5AC on the adhesive and invasive ability of pancreatic cancer cells. Methods We used two MUC5AC expressing cell lines derived from human pancreatic cancer, SW1990 and BxPC3. Small-interfering (si) RNA directed against MUC5AC were used to assess the effects...
pylori infection is considered the main cause of gastric cancer5,6. H. pylori is mostly found within the mucinous layer that covers and protects the gastric epithelium7,8. The major constituents of the gastric mucus layer are the secreted MUC5AC mucin, produced by the surface mucus-secretor ...
Next, the wells were incubated with anti-Muc5ac antibody (X100, Thermo Fisher Scientific, Inc., Waltham, MA) (Supplemental Fig. 2) for 1 hour at RT. The wells were then washed 3 times with TBST and incubated with secondary antibody (sheep anti-mouse IgG-HRP; GE Healthcare, Little ...
Engineering of a bacterial mucin-selective protease yielded a variant for fusion to a cancer antigen-binding nanobody. The resulting conjugate selectively degraded mucins on cancer cells, promoted cell death in culture models of mucin-driven growth and survival, and reduced tumor growth in mouse ...