NEO-102(Ensituximab)是一种识别MUC5AC的NPC-1C糖表位的嵌合鼠/人IgG1mAb,这是一种异常糖基化的表位,在胰腺癌和结直肠癌中优先表达。因此,NEO-102可以区分在正常组织上表达的天然MUC5AC和在肿瘤组织中表达的MUC5AC的变体。在体内小鼠模型中,未结合...
breast cancer brain metastasis.Experimental Design:In silico dataset analysis, RNA-sequence profiling of patient samples and cell lines, analysis of patient serum samples, and in vitro/in vivo knockdown experiments were performed to determine the function of MUC5AC in breast cancer brain metastasis. ...
干眼病患者眼表面粘蛋白及其分泌均发生改变(图2)。在眼表上皮,存在三种类型的粘蛋白,由结膜杯状细胞表达的大凝胶形成的粘蛋白MUC5AC,一些来自泪腺腺泡的细胞表达小溶性粘蛋白MUC7,角膜和结膜上皮细胞表达膜相关粘蛋白MUC1,4和16(图2)。 图1 粘蛋白的构造 图2 围绕在角膜表面的粘蛋白表达以及泪液粘蛋白的屏障功...
This antibody clone 1-13M1 recognizes Mucin 5AC under non-reducing conditions. ELISA or IRMA in combination with the Clone 9-13M1 or the mixture of anti-M1 monoclonal antibodies. Reactivity Human Antibody Host Mouse Isotype IgG1 Clonality Monoclonal Immunogen A BALB/c mouse ...
Sci Rep Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers Pubmed:27297822 Cytokine. Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasalepithelial cells. pubmed:27776277 J Viro...
Similarly, structural charac- terization of the glycans carried by the murine Muc5ac mucin has demonstrated that the most abundant struc- tures were based on core 2 sequences13. However, in contrast to human MUC5AC, termination with histo blood group antigens was not so frequently found in ...
This segregation between Muc5ac function and preserved type-2 inflammation is consistent with in vivo findings in nematode- infected mice. 'Allergic' type-2 inflammation stems from off-target anti-helminth responses. In nematode-infected Muc5ac À / À mice, although intestinal type-2 ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook mucinase [mu´sĭ-nās] an enzyme that acts upon mucin. Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, In...
Role of MUC1 and MUC5AC expressions as prognostic indicators in gastric carcinomas. J Surg Oncol. 2003;83:253–60. Article PubMed Google Scholar Breugelmans T, Oosterlinck B, Arras W, Ceuleers H, De Man J, Hold GL, et al. The role of mucins in gastrointestinal barrier function ...
This is likely the case for MAb-CLH2 anti-MUC5AC generated against a peptide derived from the mucin's tandem repeat [21], since the other two anti-MUC5AC MAbs are highly reactive. Similarly, CM1 anti-MUC1 was considerably less reactive than MA5 and KC4 anti-MUC1 antibodies. Capan-1 ...