Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms or methionine synthase reductase (MTRR) polymorphisms and cervical cancer. There were 372 women who performed genetic an...
Epidemiological studies have reported that polymorphisms of folate-metabolizing genes have a significant impact on male infertility. However, the results of published studies have come to different conclusions. To determine an association between folate-
Zhu BT, 2003. Medical hypothesis: hyperhomocysteinemia is a risk factor for estrogen-induced hormonal cancer. Int J Oncol 22: 499–508. CAS PubMed Google Scholar Download references Author information Authors and Affiliations Department of Mother and Child and Biology-Genetics, Section of Biology...
two first or second degree rela- tives; presence of 3 or more cases of BC in first or sec- ond degree relatives in the same side of the family tree; cases of ovarian cancer; male BC cases; presence of mul- tiple primary cancers in any organ in the same individual or family [22]....
Causal relationship between folic acid and prostate cancer risk: insights from Mendelian randomization analysis. Int J Urol. 2024;31:1356–64. Menezo Y, Elder K, Clement A, Clement P. Folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through ...
The aforementioned variants have been linked to the risk of chronic myeloid leukemia (CML)7, hepatocellular carcinoma5, and breast cancer8, as well as the pathogenesis of lipid disorders related to type 2 diabetes9. However, the role of these variations in the risk of ischemic stroke among ...
Our research suggests that smoking increases the overall risk of cancer in individuals with the C677T variant. However, no such effect was found in carriers of the A1298C variant. This may be related to the loss of enzyme activity caused by MTHFR mutation, where the enzyme activity of A129...
Folate deficiency leads to misincorporation of uracil, chromosomal instability, and DNA hypomethylation, causing altered gene expression and thus contributing to cancer development.83 Exposure to alcohol may deregulate the metabolism and levels of folate depending on polymorphic variants of enzymes involved ...
Since COMT is central to dopamine metabolism, variants are associated with lowered stress resiliency, increased sensitivity to pain10,11and the propensity to worry. COMT also plays a role in estrogen metabolism and may lower the cancer-causing potential of metabolites.12 ...
Colon cancer Depression Schizophrenia Anxiety Bipolar disorder Nerve pain Women of childbearing age suffer from reoccurring miscarriages Cardiovascular diseases Acute leukemia How to Test for MTHFR Mutation in the Gene Diagnosis is needed to be able to conclude whether the individual is only suffering from...