单核苷酸基因多态性急性淋巴细胞白血病甲氨蝶呤毒副反应目的:探讨亚甲基四氢叶酸还原酶(MTHFR)基因677位点多态性与急性淋巴细胞白血病(ALL)患儿使用大剂量甲氨蝶呤(HDMTX)化疗后毒副反应的相关性.方法:收集46例完全缓解并接受HDMTX治疗的ALL患儿外周血,提取基因组DNA,用PCR-芯片杂交法检测MTHFR基因C677T多态...
[4]. Etienne, M.C., et al., Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients. Pharmacogenetics, 2004. 14(12): p. 78 [5]. Jakobsen, A., et al., Thymidylate synthase and methylenetetrahydrofolate reductase g...
MTHFR (C677T) polymorphism determination in patients with metastatic colon cancer and its effect on the treatment with 5-fluorouracil and folinic acid 来自 掌桥科研 喜欢 0 阅读量: 14 作者:O Fernández-Castillo,A Bauza,G Calderillo,C Castro,R Herrera,LA Herrera ...
MTHFR has been implicated in a variety of physical and mental health problems, including blood clots, heart attacks, depression, bipolar disorder, schizophrenia, cancer, chronic pain, migraines, neural tube defects, recurrent MTHFR Gene Mutation, Test Kits, Treatments and Health Tips ...
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Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms or methionine synthase reductase (MTRR) polymorphisms and cervical
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome. Nutrients. 2019;11(3):608. Published 2019 Mar 13. doi:10.3390/nu11030608 [26] Finkelstein JD. The metabolism of homocysteine: pathways and regulation. Eur J Pediatr. 1998;157 Suppl 2:S40-S44. doi:10.1007/pl00014300 ...
3.Expression of Folate Receptor alpha and its Correlation with Folate, Methylenetetrahydrofolate Reductase Gene Polymorphisms and Biological Behaviour of Gastric Cancerous Tissue;叶酸受体α在胃癌组织中的表达及其与叶酸、亚甲基四氢叶酸还原酶基因多态性以及胃癌生物学行为的关系 6)MTHFR亚甲基四氢叶酸还原酶 1...
[7]MILLER A B,HOOGSTRATEN B,STAQUET M,et al.Reporting results of cancer treatment[J].Cancer,1981,47(1):207-214. [8] BENSON A B,BEKAIISAAB T,CHAN E,et al.Metastatic colon cancer,version 3.2013:featured updates to the NCCN Guidelines[J].J Natl Compr Canc Netw,2013,11(2):141-152...
(preeclampsia), an eye disorder called glaucoma, psychiatric disorders, and certain types of cancer. The 677C>T polymorphism in the MTHFR gene has also been suggested as a risk factor for cleft lip and palate, a birth defect in which there is a split in the upper lip and an opening in...