研究人员利用CRISPR筛选鉴定出PRMT1为亲铁性基因，并发现PRMT1活性参与铁死亡调节，PRMT1消融可以逆转由erastin引起的GSH含量下降和脂质过氧化增加。PRMT1是I型PRMT家族的主要成员，可以通过表观遗传改变参与基因表达的转录调控。为了阐明PRMT1是否通过转录调节铁死亡，研究人员对对照(sgCTRL)和PRMT1 KO (sgPrmt1) B16F...
研究人员利用CRISPR筛选鉴定出PRMT1为亲铁性基因,并发现PRMT1活性参与铁死亡调节,PRMT1消融可以逆转由erastin引起的GSH含量下降和脂质过氧化增加。PRMT1是I型PRMT家族的主要成员,可以通过表观遗传改变参与基因表达的转录调控。为了阐明PRMT1是否通过转录调节铁死亡,研究人员对对照(sgCTRL)和PRMT1 KO (sgPrmt1) B16F10...
MT1 and MT2 IR were both found in the intestinal epithelium, in the submucosal and myenteric plexus, and in vessels in the GI tract as well as in pancreatic islets. MT1 and MT2 IR was strongest in the epithelium of the large intestine. In the other cell types, both MT2 gene ...
Gene ID (NCBI) 114971 RRID AB_2237967 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID Q8WUK0 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is...
2024年8月22日,中国药科大学王中原/钱民先团队联合深圳大学吕德生团队在Cell Reports上在线发表了题为“CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism”的研究论文。本研究利用CRISPR-Cas9介导的基因筛选,发现蛋白精氨酸甲基转移酶1 (PRMT1)是铁死亡的关键...
2024年8月22日,中国药科大学王中原/钱民先团队联合深圳大学吕德生团队在Cell Reports上在线发表了题为“CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism”的研究论文。本研究利用CRISPR-Cas9介导的基因筛选,发现蛋白精氨酸甲基转移酶1 (PRMT1)是铁死亡的关键...
Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Properties Storage Instructions All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt. Synonyms CSHMT, Serine methylase, SHMT, SHMT1...
基因别名:AI324848; AI385541; C81125; CSHMT; mshmt; mshmt1; mshmt2; SHMT; SHMT1 UniProt ID:(Human) P34896,(Mouse) P50431 Entrez Gene ID:(Human) 6470,(Mouse) 20425 功能 glycine hydroxymethyltransferase activityprotein bindingL-allo-threonine aldolase activityamino acid bindingpyridoxal phospha...
Human PRMT1 is encoded by the PRMT1 gene located on chromosome 19 (19q13.3) and composed of 12 exons and 11 introns. At the protein level, human PRMT1 shares a high degree of homology with the different members of the PRMT family that is conserved in eukaryotes. Phylogenetic studies ...
基因又名: MT-1M; MT-IM; MT1; MT1K Gene ID: 4499 种属 Homo sapiens 基因DNA序列编号: NM_176870.3 基因DNA描述 Homo sapiens metallothionein 1M (MT1M), mRNA DNA编码区: atggaccccaactgctcctgcaccactggtgtctcctgcgcctgcaccggctcctgcacg tgcaaagagtgcaaatgcacctcctgcaagaagagctgctgctcctgctgccccgtgggc...