[1] Audinot V, Mailliet F, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. [2] Aguiar CC, Almeida AB, et al. Effects of agomelatine on oxidative stress in the brain of mice after chemically ...
中文名：褪黑素;;松果素;松果体素;3-N-乙酰基-5-甲氧基色胺;褪黑色素;褪黑激素;美拉托宁;MT1和MT2受体的内源性激素激动剂 英文名：Melatonin;MLT;Circadin;Melovine;Endogenous hormone agonist at MT1 and MT2 receptors;NSC56423; NSC113928; Regulin CAS号：73-31-4 结构式：CC(=O)NCCc1c[nH]c2c...
Melatonin is a neurohormone synthesized and secreted mainly during the dark period of the circadian cycle by the pineal gland. It has already been proved to be involved in a number of chronobiological processes, most of them being mediated by its membranar receptors MT 1 and MT 2. Both are...
Melatonin receptors MT1and MT2are G protein-coupled receptors that mediate the effects of melatonin, a hormone involved in circadian rhythms and other physiological functions. Understanding the molecular interactions between these receptors and their ligands is crucial for developing novel therapeutic agents...
MT1 and MT2 receptorsneuromuscular junctionperipheral nerve regenerationSchwann cellssciatic nerve injuryα‐LatrotoxinMelatonin is an ancient multi-tasking molecule produced by the pineal gland and by several extrapineal tissues. A variety of activities has been ascribed to this hormone in different ...
Melatonin regulates most of the physiological activities through its membrane bound MT1 and MT2 receptors in mammals. Melatonin receptors were localized on thyroid gland but their abundance on thyroid gland along with progression of age was unknown. In present study we investigated the age related ...
Although the role of melatonin, a potent endogenous antioxidant, has been highlighted in PD there is no data on the expression of melatonin receptors in affected CNS regions. We conducted an RT-PCR-based study to determine the MT1 and MT2 receptors expression in whole brain post-mortem tissue...
Compounds targeting MT1 and MT2 receptors could have potential for new anti-depressants that may improve the quality of therapeutic interventions in treating depression and relieving symptoms. In particular, a combined effect on MT1 and/ or MT2 receptors and neurotransmitter systems may be useful, ...
信号通路:MelatoninReceptors 产品描述: N-AcetylserotoninisanagonistatthemelatoninreceptorsMT1,MT2,andMT3. AmelatoninreceptorisaGprotein-coupledreceptorbindingmelatonin.Threetypesof melatoninreceptorhavebeenidentified.TheMT1andMT2receptorsubtypesareinhumans
Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors. In order to interpret the effects of melatonin ligands in rats, we need to determine their activity at the receptor subtype level in the corresponding spec... V Audinot,A Bonnaud,L Grandcolas,... - ...