Overall, the combination of genetically-modified animal models and metabolomics provide a powerful tool to characterize APAP-induced liver toxicity and undercover novel mechanism.doi:10.1096/fasebj.23.1_supplement.760.4Chi ChenFood Science and NutritionUniversity of MinnesotaSt PaulMNKristopher W Krausz...
The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization, and promotion of sui
There is still no community consensus regarding strategies for data quality review in liquid chromatography mass spectrometry (LC–MS)-based untargeted metabolomics. Assessing the analytical robustness of data, which is relevant for inter-laboratory comparisons and reproducibility, remains a challenge despite...
Metabolomicsnutritiondietary interventionmass spectrometrydoi:10.1002/9781118537282.ch9Clara IbáezLaboratory of Foodomics, Institute of Food Science Research (CIAL), National Research Council (CSIC), Madrid, SpainCarolina SimóLaboratory of Foodomics, Institute of Food Science Research (CIAL), National ...
GC-MS-based fecal metabolomics reveals gender-attributed fecal signatures in ankylosing spondylitisAnkylosing spondylitis (AS) has different clinical features in males and females. Fecal metabolites play significant roles in AS disorders. This study aimed to reveal gender-attributed fecal signatures of AS...
Using a commercial targeted MS metabolomics kit that measures 408 metabolites, we were able to quantify the levels of 201 metabolites in > 90% of CSF samples from healthy controls and patients with LM, parenchymal BT, or CNS inflammation. Most of the metabolites that were discriminative among...
Associated Vendor : An altered metabolism often points to a disease, so it is pivotal to understand the mechanisms controlling endogenous metabolites. This need has given rise to metabolomics, the comprehensive study of the small molecule metabolites that reflect the c...
which might contribute to reduction in cell proliferation and activation of cell death. A molecular network was created, and compounds annotation was made on the basis of comparison with spectral database. When the metabolomics multivariate data analysis (MVDA) results were integrated in a multi-info...
Carneiro S,Rui P,Rocha I.Yeast metabolomics:sample preparation for a GC/MS-based analysis[J].Methods Mol Biol,2014,1152(1152):197-207.Carneiro, S.; Pereira, R.; Rocha, I. Yeast Metabolomics: Sample Preparation for a GC/MS-Based Analysis. In Yeast Metabolic Engineering: Methods and ...
Furthermore, active fraction was further subjected to UPLC-QTOF-MS based targeted metabolomics to identify the phytochemicals linked to bioactivity. A complementary in-silico experiment was also performed to understand the interactions of identified molecules with CYP2E1 enzyme. It was observed that, n...