Over 90 mutant alleles of the alpha-1-antitrypsin (AAT) gene are recognized and classified by mobility on an acid starch gel. The four major categories include: F=fast, M=medium, S=slow, Z=very slow. Among 41 reported cases of AAT panniculitis, most have the ZZ phenotype with AAT ...
Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and alpha 1-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects ...
In response to toxic liver injury, HSC suffer a transdifferentiation process from a quiescent into an activated phenotype known as myofibroblasts [20]. These activated HSCs have a higher degree of proliferation and migration, hence repopulating the damaged liver, acquiring contractility by expressing ...