Relation of alpha1-antitrypsin phenotype to the performance of pulmonary function tests and to the prevalence of respiratory illness in a working population. Thorax, 31, 149-157.Cole RB, Nevin NC, Blundell G, et al. Relation of alpha-1-antitrypsin phenotype to the performance of pulmonary ...
Alpha-1-antitrypsin (Pi) phenotypes have been determined in 40 patients suffering from Down's syndrome. Thirty-six of the patients were found to have a normal M phenotype, whereas two deficient phenotypes of the MS variety were observed. In addition, two M variants were noted. The ...
Individuals with severe alpha-1-antitrypsin (alpha1AT) deficiency (phenotype Pi ZZ) are abnormally liable to develop emphysema, but it is uncertain whether those with partial alpha1AT deficiency (phenotypes Pi MS and MZ) are similarly susceptible. This study was undertaken to determine the frequenc...
alpha 1-AntitrypsinGenetic MarkersHepatitis B AntibodiesRiskPhenotypeFemaleMaleThe BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as ...
The finding is recorded of typical a1-antitrypsin globules, confirmed by immunofluorescence and immunoperoxidase methods, in the hepatocytes of a patient shown to have a normal serum antitrypsin level and normal phenotype (TiM) for a1-antitrypsin. The identification of such globules can no longer be...
A comparable control group contained 3.68% MZ, 6.23% MS, 0.71% SZ-SS, but no ZZ Pi phenotype. 展开 关键词: Alpha1-antitrypsin Allergy Pi phenotyping Serum trypsin inhibitory capacity (STIC) DOI: 10.1093/ajcp/64.3.297 被引量: 39
To study further the role of intermediate alpha1-antitrypsin (AAT) deficiency in chronic obstructive pulmonary disease (COPD), AAT Pi-types and serum-trypsin-inhibitory-capacity (STIC) were measured in 965 patients with COPD. Heterozygosity of the Z variant was the major cause of intermediate AAT...
Pi type MZ had an a-1-antitrypsin concentration of 7.0 Trypsin inhibitory activity was first demonstrated in human mglliter at 7 wk postpartum and 4.1 rnglliter at 5 2 wk. It milk by Laskovski and Laskovski (13). Both A l A T and a-1- has been previously demonstrated that enhanced...
Heterozygosity for different AAT alleles results in intermediate reductions in plasma AAT levels according to resultant Pi phenotype (see Table 52-1). The concept of “deficient” levels of AAT derives from the observation that serum levels of AAT below a threshold level (11 μM) are associated...
Individuals with severe alpha-1-antitrypsin (alpha1AT) deficiency (phenotype Pi ZZ) are abnormally liable to develop emphysema, but it is uncertain whether those with partial alpha1AT deficiency (phenotypes Pi MS and MZ) are similarly su... RB Cole,NC Nevin,G Blundell,... - 《Thorax》 被...