Here, we report that a single allele of the Mrp8-cre/ires-eGFP transgene predisposes mice to CAIA, likely due to the interfered expressions of genes close to the insertion site. These findings underscore the need for rigorous control strategies when using conditional mouse strains. Materials and...
To better understand inflammasome-driven pathology, we characterised haematopoietic cell populations in sick vs. control iOvaFla mice. Complete blood count (CBC) analysis of peripheral blood revealed that iOvaFla; LysM-Cre+/−mice have decreased haematocrit levels compared to LysM-Cre−/−litterma...