Since 1796, the year Edward Jenner first demonstrated the viability of theVariolaevaccine for inducing immunity against smallpox, vaccines have saved millions of lives from a plethora of infectious micro-organisms. Nowadays, vaccines look very different from their predecessors. They are no longer des...
Since 1796, the year Edward Jenner first demonstrated the viability of theVariolaevaccine for inducing immunity against smallpox, vaccines have saved millions of lives from a plethora of infectious micro-organisms. Nowadays, vaccines look very different from their predecessors. They are no longer des...
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an ongoing research area that started before these versatile nanoparticles were successfully used as COVID-19 vaccines. Currently, efforts are underway to harness this platform for oncology therapeutics, mainly focusing on...
mRNA vaccines have come up with huge success against SARS-CoV-2; Pfizer-BioNTech and Moderna vaccines have resulted in >90% efficacy with efficient translocation, expression, and presentation of antigen to the host immune system. Herein, based on the same approach a mRNA vaccine construct has ...
Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. BCG is the only approved vaccine. However, it has limited global efficacy. Pathogens could affect the transcription of host genes, especially the ones related to the imm
mRNA vaccine for cancer immunotherapy. Mol Cancer. 2021;20(1):41. Article CAS PubMed PubMed Central Google Scholar Bonehill A, Heirman C, Tuyaerts S, Michiels A, Breckpot K, Brasseur F, Zhang Y, Van Der Bruggen P, Thielemans K. Messenger RNA-electroporated dendritic cells presenting...
in silico vaccine design strategy seems to be quite effective, but it might not be efficient enough to catch pace with the advent of newer pathogens. All findings must be thoroughly and extensively analyzed in order to identify antigenic regions for designing an effective vaccine, which presents ...
9. COVID-19 mRNA vaccine candidates and recommended dosage for different ages 10. Transportation of COVID-19 mRNA vaccines and its effect on properties 11. Can the genetic content of COVID-19 mRNA vaccines integrates into the human genome? 12. The impact of mRNA vaccines on the next generat...
Clin. Cancer Res. 21, 1019–1027 (2015). CAS PubMed Google Scholar Ott, P. A. et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature 547, 217–221 (2017). This work, along with the studies by Carreno et al. (2015) and Sahin et al. (2017), ...
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature 547, 222–226 (2017). Article CAS PubMed Google Scholar Keskin, D. B. et al. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature 565, 234–239 (...