[4]Xiao Y, Chen J, Zhou H, et al. Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy[J]. Nature Communications, 2022, 13: 758. [5]Cheng Q, Wei T, Farbiak L, et al. Selective organ targeting (SORT) nanoparticl...
[4]Xiao Y, Chen J, Zhou H, et al. Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy[J]. Nature Communications, 2022, 13: 758. [5]Cheng Q, Wei T, Farbiak L, et al. Selective organ targeting (SORT) nanoparticl...
近日,北京大学未来技术学院程强研究员(星锐医药科学创始人)、中科院动物研究所魏妥研究员(星锐医药科学顾问)作为共同通讯作者,在 Advanced Materials 期刊发表了题为:Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy 的长篇综述论文。 该综述详细介绍了基于mRNA-LNP的癌症治疗,总结了mRNA-LNP制剂的主...
近日,来自北京大学的程强(星锐医药科学创始人)课题组与中科院动物所魏妥(星锐医药科学顾问)在期刊Advanced Materials上发表了题为“Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy(LNP递送mRNA 用于癌症治疗)”的长篇综述文章。该综述总结了LNP-mRNA配方的主要发展策略,讨论了目前具有代表性的mRNA癌...
[4]Xiao Y, Chen J, Zhou H, et al. Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy[J]. Nature Communications, 2022, 13: 758. [5]Cheng Q, Wei T, Farbiak L, et al. Selective organ targeting (SORT) nanoparticl...
近日,北京大学未来技术学院程强研究员(星锐医药科学创始人)、中科院动物研究所魏妥研究员(星锐医药科学顾问)作为共同通讯作者,在Advanced Materials期刊发表了题为:Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy的长篇综述论...
receptor (CAR) in participants (pts) with HER2 overexpressing solid tumorsJournal for ImmunoTherapy of Cancer 2023;11:doi: 10.1136/jitc-2023-SITC2023.0635 [7] BioNTech Presents Positive Phase 1/2 Data Update for CAR-T Cell Therapy Candidate BNT211 in Advanced Solid Tumors at ESMO Congress 2023....
The therapeutic methods disclosed herein comprise, e.g., the administration of a combination therapy disclosed herein for the treatment of cancer, e.g., by reducing the size of a tumor or inhibiting the growth of a tumor, in a subject in need thereof. In some aspects, the combination ...
来源:Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy 将癌症患者自身的T细胞分离出来,通过基因工程化改造(病毒载体或者mRNA技术),使其表面表达嵌合抗原受体,再回输到患者体内,称为CAT疗法。嵌合抗原受体由胞外抗原结合结构域和胞...
[2]Springfeld, Christoph et al. “Neoadjuvant therapy for pancreatic cancer.” Nature reviews. Clinical oncology vol. 20,5 (2023): 318-337. [3]Rojas, Luis A et al. “Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.” Nature, 1–7. 10 May. 2023, ...