Methods:Tumor-specific neoantigens and aberrantly overexpressed tumor-associated antigens were identified for glioblastoma and medulloblastoma tumors using our cancer immunogenomics pipeline called Open Reading Frame Antigen Network (O.R...
For the first time, scientists have tested a messenger RNA (mRNA) vaccine in a patient with a deadly form of brain cancer — and it triggered a strong immune response. The vaccine, which was described in a study published on May 1 in the journal Cell, was created by extr...
“We started by asking, where is the highest unmet need that also allows us to prove out the thesis of this technology? And where will this approach have therapeutic relevance that is a quantum leap forward from what anyone else is doing?” Becraft says. “The first place we looked was ...
vaccine, the delivery system as well as administration route, involved in the optimization for its therapeutic application. In general, although mRNA cancer vaccines have advanced quickly, there have been many issues remain to be solved to promote the feasibility and efficacy [21,22]. To date, t...
靶向个性化抗原的优势在于可以实现较高的特异性,并且能够与检查点阻断治疗相结合,增加其体内T细胞的反应性。 参考资料: 1.Clinical advances and ongoing trials of mRNA vaccines for cancer treatment. 2.Evolution of the market for mRNA technology.
mRNA vaccines have been revolutionary in terms of their rapid development and prevention of SARS-CoV-2 infections during the COVID-19 pandemic, and this technology has considerable potential for application to the treatment of cancer. Compared with traditional cancer vaccines based on proteins or pept...
参考资料: 1.Clinical advances and ongoing trials of mRNA vaccines for cancer treatment. https://doi.org/10.1016/S1470-2045(22)00372-2 2.Evolution of the market for mRNA technology. https://doi.org/10.1038/d41573-021-00147-y
mRNA药物最新研究进展-202403-9 1. Antiangiogenic Therapeutic mRNA Delivery Using Lung-Selective Polymeric Nanomedicine for Lung Cancer Treatment 译：使用肺选择性聚合纳米药物进行抗血管生成治疗性mRNA 递送用于肺癌治疗 作者列表:Le ND;Nguyen BL;Patil BR;Chun H;Kim S;Nguyen TOO;Mishra S;Tandukar S;...
MRNA technology has also been of interest to cancer researchers and physicians. One of the major obstacles in cancer treatment is the low response rate in patients who receive immune checkpoint inhibitors to prevent animmune responsefrom being so strong that it destroyshealthy cellsin the body. ...
[1]BioNTech:Could Covid vaccine technology crack cancer?.BBC [2]Can mRNA Vaccines Help Treat Cancer?.NIH [3]Clinical advances and ongoing trials of mRNA vaccines for cancer treatment.The Lancet Oncology.VOLUME 23,ISSUE 10,E450-E458,OCTOBER 01,2022.doi.org/10.1016/S1470-2045(22)00372-2 [...