1.mRNA-Based Therapeutics in Cancer Treatment. 2.mRNA mediates passive vaccination against infectious agents, toxins, and tumors. 3.Elimination of large tumors in mice by mRNA-encoded bispecific antibodies. 4.mRNA Delivery of a Bispecific Single-Domain Antibody to Polarize Tumor-Associated Macrophages ...
mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowledge that mRNA is one of nature’s core buildin
随着mRNA稳定性、结构和递送系统等技术的快速发展，mRNA治疗性疫苗已在多癌种人群中开展了临床试验并取得积极结果。2022年10月，哥本哈根大学Inge Marie Svane作为通讯作者在Lancet Oncol期刊(IF: 54.433)发表综述文章《Clinical advances and ongoing trials on mRNA vaccines for cancer treatment》，基于mRNA递送系统...
2022年8月20号,这项研究成果以预印本的形式上传在BioRxiv:Comb-structured mRNA vaccine tethered with short doublestranded RNA adjuvants maximizes cellular immunity for cancer treatment。 导读 新知:佐剂dsRNA序列设计 新知:佐剂dsRNA合成制备 新知:佐剂dsRNA参数优化 新知:佐剂dsRNA不影响mRNA翻译效率 dsRNA-mRNA嵌...
mRNA药物最新研究进展-202403-9 1. Antiangiogenic Therapeutic mRNA Delivery Using Lung-Selective Polymeric Nanomedicine for Lung Cancer Treatment 译：使用肺选择性聚合纳米药物进行抗血管生成治疗性mRNA 递送用于肺癌治疗 作者列表:Le ND;Nguyen BL;Patil BR;Chun H;Kim S;Nguyen TOO;Mishra S;Tandukar S;...
garnered widespread interest for their potential to revolutionize cancer treatment. In this study, we developed a novel and scalable approach for the production of personalized mRNA-based therapeutics that target multiple tumor reje...
2022年10月,哥本哈根大学Inge Marie Svane作为通讯作者在Lancet Oncol期刊(IF: 54.433)发表综述文章《Clinical advances and ongoing trials on mRNA vaccines for cancer treatment》,基于mRNA递送系统分类,对当前mRNA肿瘤治疗性疫苗的临床研究现状进行了深度回顾。 01 mRNA肿瘤治疗性疫苗的作用机制 mRNA疫苗通过诱导或加强...
12.Adjuvants, the Elephant in the Room for RNA Vaccines 佐剂,RNA疫苗中刻意忽视的问题 13.Advances in mRNA Delivery and Clinical Applications mRNA传递和临床应用的进展 14.Lipid Nanoparticles to Harness the Therapeutic Potential of mRNA for Cancer Tr...
Additionally, we summarize preclinical studies and clinical trials to provide valuable insights into the current status of mRNA vaccines in cancer treatment. Furthermore, we delve into a systematic discussion on the significant challenges facing the current development of mRNA tumor vaccines. These ...
And by the time immune therapy begins, “the cancer is out of control now and so now the immune response is like a water gun in the face of a forest fire," Sayour told Live Science. Up until now, cancer vaccines being tested have aimed to mount an immune response to...