Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy Cancer immunotherapy, which harnesses the power of the immune system, has shown immense promise in the fight against malignancies. Messenger RNA (mRNA) sta... J Han,J Lim,CPJ Wang,... - 《Nano Convergence》 被引量: 0发表...
1. mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond 译：用于癌症免疫治疗的mRNA 递送系统：脂质纳米颗粒及其他 作者列表:Estapé Senti M;García Del Valle L;Schiffelers RM 发表日期: 2024 Mar 期刊:Adv Drug Deliv Rev 影响因子: 16.1 中科院分区: 医学 1区 DOI: 10.1016...
mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowledge that mRNA is one of nature’s core buildin
1. mRNA Vaccines: The Dawn of a New Era of Cancer Immunotherapy. Front Immunol.2022; 13: 887125. 2. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat RevDrug Discov. 2021 Aug 25 : 1–22. 3. Recent advan...
Nevertheless, the inherent structural instability of mRNA requires the development of effective delivery systems. Lipid nanoparticles (LNPs) have emerged as significant candidates for mRNA delivery in cancer immunotherapy, providing both protection to the mRNA and enhanced intracellular delivery efficiency. ...
[Key words]mRNA vaccine; Delivery system; Anti-tumor therapy; Immunotherapy 肿瘤治疗方法的探究和开发是改善人类健康的关键环节。环境因素或遗传因素的改变可能是导致肿瘤形成的重要原因。尽管目前已有许多有效的肿瘤治疗方法进入临床或临床...
1.mRNA Vaccines: The Dawn of a New Era of Cancer Immunotherapy. Front Immunol.2022; 13: 887125. 2. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat RevDrug Discov. 2021 Aug 25 : 1–22. 2. Recent advances in mRNA vaccine technology. Curr Opin Immun...
In 2014,Modernadisclosed a new technology that it says will more safely deliver mRNA. It is called V1GL. According to the profile of Ying Bo, “His work has led to the nomination of “N1GL” as the next-gen lead of mRNA delivery in cancer immunotherapy. At Dicerna Pharmaceuticals, Mr ...
1. mRNA Vaccines: The Dawn of a New Era of Cancer Immunotherapy. Front Immunol.2022; 13: 887125. 2. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat RevDrug Discov. 2021 Aug 25 : 1–22. 2. Recent advances in mRNA vaccine technology. Curr Opin Imm...
Here, we discuss the promise of analysing mRNA processing events in cancer cells, with an emphasis on mRNA splicing, for the identification of potential new targets for cancer immunotherapy. Further, we highlight the challenges that must be overcome for this new avenue to have clinical ...