mature mRNA. This mature mRNA is then translated into a polymer of amino acids: a protein, ...
题为:Rootstock-scion exchanging mRNAs participate in the pathways of amino acids and fatty acid metabolism in cucumber under early chilling stress;这两篇文章发表时间相差一个月,分析方法及思路也很类似,文章具体内容别的号已有解读,这里不再详述;然而我感兴趣的是如何去鉴定这些异种间长距离运输的mRNA...
Amino Acids in Protein Can Be Assembled Without DNA and mRNA: StudyDNA is known to provide the instructions for the production of proteins, but researchers have found evidence that amino acids can be assembled by another protein and without instructions from the DNA and mRNA.Tech Times...
mRNA vaccines have elicited potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus and others, especially in recent years, using lipid-encapsulated or naked forms of sequence-optimized mRNA. Diverse approaches to mRNA cancer vaccines, including ...
Regions of a protein in which specific amino acids are over-represented compared with their amino acid proportions found in the proteome. Stress granules Membraneless cytoplasmic liquid–liquid phase compartments where RNA and RNA-bound proteins are found under conditions of cellular stress. P-bodies ...
作为美国食品和药品管理局(Food and Drug Administration,FDA)批准用于药物递送的药用辅料,PLGA可与阳离子脂质或阳离子聚合物混合使用来增强mRNA的转染效果,如(2,3-二油酰基-丙基)-三甲基氯化铵[(2,3-dioleyl-propyl)-rimethylamine,DOTAP][...
Three amino acid transporter genes (AAP3-5) were isolated from Arabidopsis by complementation of a yeast mutant defective in histidine uptake. Transport is driven against a concentration gradient and sensitive to protonophores. Analysis of the substrate specificity demonstrates that the carriers have a...
(coding sequences). The production of a functional protein involves the transcription of the gene from DNA into RNA, the removal of introns and splicing together of exons, the translation of the spliced RNA sequences into a chain of amino acids, and the posttranslational modification of the ...
Purification and properties of a HeLa cell enzyme able to remove the 5′-terminal protein from poliovirus RNA. J. Biol. Chem. 255, 6739–6744 (1980). CAS PubMed Google Scholar Cong, P. & Shuman, S. Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP ...
However, a series of challenges remains to be addressed before mRNA can be established as a general therapeutic modality with broad relevance to both rare and common diseases. An array of new technologies is being developed to surmount these challenges, including approaches to optimize mRNA cargos,...