A polymorphic set of proteins expressed on the surface of all nucleated cells that present antigen to CD8+ (including cytotoxic) T cells in the form of proteolytically processed peptides, typically 8–11 amino acids in length. MHC class II A polymorphic set of proteins expressed on professional...
a | Global analysis of mRNA–protein interactions can be performed with proximity-based labelling techniques using ascorbate peroxidase (APEX) or the biotin ligase BioID assay (also known as BirA). A bait protein is fused to the APEX or BirA enzyme, the...
Amino acids act through a number of signaling pathways and mechanisms to mediate control of gene expression at the level of mRNA translation. This report reviews recent findings that illustrate the manner through which amino acids act to regulate the initiation phase of mRNA translation. The report...
Purification and properties of a HeLa cell enzyme able to remove the 5′-terminal protein from poliovirus RNA. J. Biol. Chem. 255, 6739–6744 (1980). CAS PubMed Google Scholar Cong, P. & Shuman, S. Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP ...
在mRNA递送领域,多种含胺基的聚酯已被开发用于mRNA递送,包括聚(β-氨基酯)[poly(β-aminoester),PBAEs,4]、氨基聚酯(amino polyester,APEs)和电荷改变释放转运体(charge-altering releasable transporters,CARTs,5和6)等。其中,PBAEs 是经典...
into processed, mature mRNA. This mature mRNA is then translated into a polymer of amino acids:...
The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. ...
(Extended Data Fig.6i–l). Although eL24 bears partial structural homology to bL19, it lacks N-terminal residues that are critical to mediating h14 contact. C-terminal elements of eL24 instead principally contributed to eB13, contacting h6 adjacent to B8, while the approximately 60 amino ...
It has an open reading frame of 612 bp coding for a signal peptide of 17 amino acids (aa) and a mature hormone of 187 aa residues. Based on the aa sequence of the mature hormone, grouper GH shows higher sequence identity (>76%) to GHs of perciforms than to GHs of cyprinids and ...
messenger RNA (mRNA),moleculeincellsthat carries codes from theDNAin thenucleusto the sites ofproteinsynthesisin thecytoplasm(theribosomes). The molecule that would eventually become known as mRNA was first described in 1956 by scientists Elliot Volkin and Lazarus Astrachan. In addition to mRNA, ...