The oncofetal mRNA-binding protein IGF2BP1 belongs to a conserved family of RNA-binding proteins. It primarily promotes RNA stability, regulates translation and RNA localization, and mediates gene expression through its downstream effectors. Numerous stu
225,242]. The successful development of mRNA-based COVID-19 vaccines has opened up exciting new opportunities for novel mRNA-based drugs and vaccines to combat a variety of challenging diseases. Some of the most promising applications
Antibody technology is widely used in the fields of biomedical and clinical therapies. Nonetheless, the complex in vitro expression of recombinant proteins, long production cycles, and harsh storage conditions have limited their applications in medicine, especially in clinical therapies. Recently, this di...
In 1978, two different research groups demonstrated that mRNA could be successfully delivered into mouse cells and human cells by encapsulating the nucleic acids in liposome vesicles [12,13]. However, the lack of a suitable delivery vehicle remained a critical challenge in the field for many years...
Amino Acids 2007; 32: 101–108. 58 Wassell J. Haptoglobin: function and polymorphism. Clin Lab 2000; 46: 547–552. 59 Asleh R, Marsh S, Shilkrut M, Binah O, Guetta J, Lejbkowicz F et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to dia- betic ...
Initial and postsupplementation blood chemistry profiles were performed (SmithKline Beecham, Collegeville, PA), and subjects whose profiles fell out of any normal range were excluded from the study. The profile included total cholesterol, HDL cholesterol, glucose, urea nitrogen, creatinine, Na, K, ...
Lipid nanoparticle-assisted mRNA inhalation therapy necessitates addressing challenges such as resistance to shear force damage, mucus penetration, cellular internalization, rapid lysosomal escape, and target protein expression. Here, we introduce the in
strings together amino acids in the order specified by the sequence of elements in the mRNA molecule. Since the (10) amount of mRNA in a cell determines the amount of the corresponding protein, factors affecting the abundance of mRNA’s play a major part in the normal functioning of a cell...
RPL11 (black) is at the median of the dynamicity distribution (Δ = 0.8e-2). OCM2 (a calmodulin) and one of the isoforms of hemoglobin zeta (HBZ), a form of alpha globin produced in the yolk sack of mammals, are among the most dynamic (Δ = 0.571; 35 degrees difference) proteins...
As proteins are composed of 20 different amino acids as building blocks, the physicochemical properties differ from protein to protein, implying that for each protein the buffer for storage and formulation should be optimized specifically. DNA and mRNA on the other hand are composed of a mere four...