Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects. In this regard, lipid nanoparticles have been successfully utilized to improve mRNA delivery and protec...
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in combination with CPI therapy. Safety, tolerability and recommended phase 2 dose (RP2D) of an individualized, h...
Antibody technology is widely used in the fields of biomedical and clinical therapies. Nonetheless, the complex in vitro expression of recombinant proteins, long production cycles, and harsh storage conditions have limited their applications in medicine, especially in clinical therapies. Recently, this di...
These antigens are common, but have low tumor specificity and are subject to central tolerance, thus limiting their immunogenicity. Cancer testis anti- gens (CTAs) are another category of TAAs, which usually over expressed in a variety of cancers, as well as normally expressed in the normal ...
strings together amino acids in the order specified by the sequence of elements in the mRNA molecule. Since the (10) amount of mRNA in a cell determines the amount of the corresponding protein, factors affecting the abundance of mRNA’s play a major part in the normal functioning of a cell...
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune s
of SARS-CoV-2 isolate Wuhan-Hu-1 consists of 29,881 nucleotides (GenBank accession number: MN908947) with a methylated 5′-cap and a 3′-poly(A) tail, consisting of 9860 amino acids encoding 16 nonstructural proteins (nsp), 9 accessory proteins, and 4 structural proteins. The four ...
normal tissues while up-regulated in tumor such as EGFR and HER2 [11]. These antigens are common, but have low tumor specificity and are subject to central tolerance, thus limiting their immunogenicity. Cancer testis antigens (CTAs) are another category of TAAs, which usually over expressed ...
Initial and postsupplementation blood chemistry profiles were performed (SmithKline Beecham, Collegeville, PA), and subjects whose profiles fell out of any normal range were excluded from the study. The profile included total cholesterol, HDL cholesterol, glucose, urea nitrogen, creatinine, Na, K, ...
Amino Acids 2007; 32: 101–108. 58 Wassell J. Haptoglobin: function and polymorphism. Clin Lab 2000; 46: 547–552. 59 Asleh R, Marsh S, Shilkrut M, Binah O, Guetta J, Lejbkowicz F et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to dia- betic ...