Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects. In this
The oncofetal mRNA-binding protein IGF2BP1 belongs to a conserved family of RNA-binding proteins. It primarily promotes RNA stability, regulates translation and RNA localization, and mediates gene expression through its downstream effectors. Numerous stu
strings together amino acids in the order specified by the sequence of elements in the mRNA molecule. Since the (10) amount of mRNA in a cell determines the amount of the corresponding protein, factors affecting the abundance of mRNA’s play a major part in the normal functioning of a cell...
These antigens are common, but have low tumor specificity and are subject to central tolerance, thus limiting their immunogenicity. Cancer testis anti- gens (CTAs) are another category of TAAs, which usually over expressed in a variety of cancers, as well as normally expressed in the normal ...
Antibody technology is widely used in the fields of biomedical and clinical therapies. Nonetheless, the complex in vitro expression of recombinant proteins, long production cycles, and harsh storage conditions have limited their applications in medicine,
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune s
of SARS-CoV-2 isolate Wuhan-Hu-1 consists of 29,881 nucleotides (GenBank accession number: MN908947) with a methylated 5′-cap and a 3′-poly(A) tail, consisting of 9860 amino acids encoding 16 nonstructural proteins (nsp), 9 accessory proteins, and 4 structural proteins. The four ...
normal tissues while up-regulated in tumor such as EGFR and HER2 [11]. These antigens are common, but have low tumor specificity and are subject to central tolerance, thus limiting their immunogenicity. Cancer testis antigens (CTAs) are another category of TAAs, which usually over expressed ...
Initial and postsupplementation blood chemistry profiles were performed (SmithKline Beecham, Collegeville, PA), and subjects whose profiles fell out of any normal range were excluded from the study. The profile included total cholesterol, HDL cholesterol, glucose, urea nitrogen, creatinine, Na, K, ...
Amino Acids 2007; 32: 101–108. 58 Wassell J. Haptoglobin: function and polymorphism. Clin Lab 2000; 46: 547–552. 59 Asleh R, Marsh S, Shilkrut M, Binah O, Guetta J, Lejbkowicz F et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to dia- betic ...