直奔主题,新的一周给大家带来单细胞数据库第六趴,“双剑合璧”——人和鼠单细胞图谱,Human Cell Atlas和Mouse Cell Atlas两类单细胞数据库,一起来康康吧~! Human … 酸菜发表于解螺旋 CNS级别SCI必备!这两款人、鼠单细胞图谱数据库,太硬核了! 嗨,小伙伴们大家好!直奔主题,新的一周给大家带来单细胞数据库第...
we apply single-cell assay for transposase-accessible chromatin sequencing to profile the genome-wide chromatin accessibility of 9,549 single cells from the mOB.Based on single-cell epigenetic signatures,mOB cells are classified into 21 clusters corre-sponding to 11 cell types.We identify distinct ...
Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence3, genomic instability4 and changes in the immune system2. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides ...
it has historically been challenging to elucidate the cell type-specific mechanisms that promote follicular depletion and ovarian failure. Data showing age-related changes in ovarian transcriptional programs within cellular subtypes are limited, particularly those pertaining to mice. Single-cell analyses of ...
(E) Comparison of cell fraction of Lgr5 mRNA expressing cells from Single-Cell RNAseq. (n = 5 young, 6 old biologically independent animals, 1-tailed unpaired t-test; Data are represented as mean +SD). ns, p>=0.05; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001...
MouseCellAtlas ：小鼠单细胞图谱 过去，基因测序的常规技术是按组对细胞进行分析的，每个单细胞的特异性都会被忽略。单细胞组学技术使我们能够从单个细胞的水平上更为精确地解析细胞的分化、再生、衰老以及病变，但这项技术存在着成本高、精度低的问题。因此，郭国骥团队设计出了基于琼脂糖材料的高通量单细胞捕获系统。
A single-cell atlas of chromatin accessibility in mouse organogenesis Keyong Sun Xin Liu Xun Lan Nature Cell Biology(2024) Retinoic acid induces human gastruloids with posterior embryo-like structures Nobuhiko Hamazaki Wei Yang Jay Shendure
While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear, other brain-resident myeloid cells remain less well understood. By dissecting border regions and combining single-cell RNA-sequencing with high-dimensional cytome
Single-cell DNA methylome atlas We used snmC-seq22to profile genome-wide 5mC at single-cell resolution (Fig.1a) across the cortex, HIP, striatum and pallidum (or cerebral nuclei, CNU), and olfactory areas (OLF) (Fig.1b–e) using adult male C57BL/6 mice16. In total, we analysed 45...
Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning Yue Pang Yating Qin Guangyi Fan Nature Communications(2025) Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study ...