158 Phenotypic screening of a library of compounds using cell death as a readout identified ON1231320 as a PLK2-specific small molecule inhibitor. The identified isoform-selective PLK2 inhibitor ON1231320 caused apoptotic cell death in cultured tumor cell lines and showed significant tumor growth ...
The expression levels of TrxR1 in some human carcinoma cell lines are nearly 10 times higher than those in normal cells. Ethaselen is a novel antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR. In this study we explored the relationship ...
In addition to modeling chromosomal rearrangements in cell lines and ES cells, viral delivery of the CRISPR-Cas9 system to generate the Eml4-Alk rearrangement in non-small-cell lung cancers (NSCLCs) [22, 39] has been reported in mouse models. Our groups have recently shown that hydrodynamic ...
Model selection, dosing and scheduling can be underpinned by earlier work, including analysis and evaluation of a broad panel of cell lines in vitro (e.g. the catalogue of somatic mutations in cancer (COSMIC) cell line project9), next-generation sequencing of tumour samples and analysis of cli...
Of the two main histopathologic classifications, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), approximately 85% of lung cancer falls into the NSCLC category and can be further subclassified as adenocarcinoma, squamous cell carcinoma (SCC), and large cell carcinoma. The...
Consequently, the aim of this study was to investigate whether the HSP90‑inhibitor onalespib could reduce NET cell growth and act as a radiosensitizer when used in combination with 177Lu‑DOTATATE. The NET cell lines BON, NCI‑H727 and NCI‑H460, were first characterized with regards...
The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer (NSCLC) compared with the normal tissues (1,2). Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQO1 in the prevention of tumor development (1). ...
Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH. PLOS Genet. 2022;18: e1010362. PubMed PubMed Central CAS Google Scholar Hollern DP, et al. E2F1 drives breast cancer metastasis by regulating the target gene FGF13 and altering cell migration. Sci Rep. 2019;9:10718. ...
Amongst all cancers, lung cancer accounted for about 13% of the newly diagnosed cancers but 27% of the cancer-caused mortality2 with non-small cell lung cancer (NSCLC) accounting for approximately 84% of the lung cancer, half of which are metastatic at time of diagnosis3,4. It is now ...
The human NSCLC cell lines H460 and H1299 were cultured in RPMI-1640 Medium (Sigma-Aldrich, Poole, UK), supplemented with 10% fetal bovine serum. The mouse embryo fibroblast cell line NIH/3T3 was cultured in Dulbecco’s Modified Eagle’s Medium with 10% bovine calf serum. The rat embryo...