immunotherapysyngeneic mouse modelEsophageal cancer (EC) is the sixth leading cause of death from cancer worldwide [1]. It has remained a large burden in the world, especially in China [2]. Esophageal squamous cell carcinoma (ESCC) is the major histological subtype of EC and is mostly ...
Esophageal cancer (EC) is the sixth leading cause of death from cancer worldwide [1]. It has remained a large burden in the world, especially in China [2]. Esophageal squamous cell carcinoma (ESCC) is the major histological subtype of EC and is mostly regarded as a 'silent' tumor in ...
Esophageal cancer, including esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), has a poor prognosis and limited therapeutic options. Chimeric antigen receptor (CAR)-T cells represent a potential ESCC treatment. In this study, we examined CD276 expression in healthy and es...
ESCC is a tumor of the esophagus.,disease:Defects in TP53 are involved in head and neck squamous cell carcinomas (HNSCC) [MIM:275355].,disease:Defects in TP53 are involved in oral squamous cell carcinoma (OSCC). Cigarette smoke is a prime mutagenic agent in cancer of the aerodigestive ...
The methylene tetrahydrofolate reductase (MTHFR) gene is polymorphic, and the p16, MGMT, and MLH1 genes are methylated during esophageal squamous cell carcinoma (ESCC). A diet rich in FA supplies the methyl group and influences the methylation process. Clinically, dietary FA has been ...
These miRNAs are named ESC-specific cell cycle (ESCC) family of miRNAs12. The miR-302-367, miR-290-295, miR-17-92b, miR-106a- 363 and miR-106b-25 cluster of miRNAs belong to the ESCC family of miRNAs12. The miR-302-367 cluster is comprised of miR-302b, miR-302c, miR-302a,...
Japanese carriers display no significant clinical abnormality [86]. Patients carrying biallelic mutations inFANCD1demonstrate an early-onset leukemia (median age 2.2 years), compared with 13.4 years in other FA patients [87]. Increased risk of esophageal squamous cell carcinoma (ESCC) was reported to...
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cell types in human even have unambiguous counterparts in the mouse. In addition, several fundamental questions remain to be elucidated. First, it is unclear whether a single cell type (radial glia;Bonilla et al., 2008) can give rise to all the diverse progeny found in the ventral midbrain...