One such model is the MC38 murine CRC cell line, derived from a grade-III adenocarcinoma chemically induced in a female C57BL/6 mouse. The aim of this study was to analyze the immune infiltration in subcutaneous MC38 tumors and track responses to various therapeutics. All animal work was ...
Colitis-associated colorectal cancer (CAC) is a typical type of CRC that evolves from inflammation (specifically, IBD) to tumor transformation. In the context of intestinal inflammation, the intestinal mucosal epithelium undergoes low-grade dysplasia, which then progresses to high-grade dysplasia and ...
Nickel is a potent carcinogen and, at high concentrations, is toxic to mammalian cells. The effects associated with nickel exposure are well-documented but its mechanism of action in the cell has not yet been fully described. In order to understand the metabolic fate of nickel in mammalian cell...
The general structure of an ERV is analogous to that of an integrated provirus, with flanking long terminal repeats (LTRs) containing the transcriptional regulatory signals, specifically enhancer, * Correspondence: dmager@bccrc.ca 1Terry Fox Laboratory, BC Cancer and Department of Medical Genetics,...
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with the increase of the 5-FU loading. Their research study also estimated thein vitroandin vivocytotoxicities of the released 5-FU using HCT-116 (human CRC cells) and female tumour-bearing athymic 6 to 8 weeks old BALB/cnude mice. Together, the cell cycle andapoptosisanalysis were ...
New York: Chapman and Hall/CRC; 2001. 168. Fujita A, Sato JR, Garay-Malpartida HM, Morettin PA, Sogayar MC, Ferreira CE. Time-varying modeling of gene expression regulatory networks using the wavelet dynamic vector autoregressive method. Bioinformatics. 2007;23(13): 1623–30. 169. Shojaie...
Because the MC3T3-E1 cell line expresses estrogen receptors and can differentiate into osteoblasts, it has been a useful model for studying the molecular mechanism of osteogenesis26. RNA-seq analysis is a powerful tool for examining gene expression at the whole genome level. In this study, we ...
In Gad SC, editor: Animal models in toxicology, Boca Raton, FL, 2015, CRC Press, pp. 21–152. d Data obtained from Pritchett KR, Taft RA: Reproductive biology of the laboratory mouse. In Fox JG, Barthold SW, Davisson MT, et al., editors: The mouse in biomedical research, ed 2, ...
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