To facilitate the elucidation of the mechanisms underlying these processes and to identify the molecular regulators, particularly at the early stages, we developed a mouse model of hepatic metastasis of CRC by cecal implantation of a mouse adenocarcinoma cell line in an immune competent host that ...
It is an inbred strain of mouse proficient in pinealmelatoninproduction. This line has been used to developknockout micefor the MT1, MT2, and MT1/MT2melatonin receptors. C57 mouse It is an inbred strain of mice that produces little to no melatonin in the pineal gland due to mutations in...
For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type 1 diabetes (T1D). However, while sharing many similarities, it is becoming increasingly appreciated that there are als...
Costa,CRC Critical Rev. Toxicol. R. O. McCeellan, ed., in press. C. T. Walsh and W. H. Orme-Johnson,Biochem. 26, 4901 (1987). Article CAS Google Scholar D. Bonam, M. C. McKenna, P. J. Stephens, and P. W. Ludden,Proc. Natl. Acad. Sci. USA 85, 31 (1988). ...
rhizome namely, coptisine, jatrorrhizine, and palmatine, we found that berberine had the most effective activity in CRC cell lines [41]. Based on these findings, we selected berberine for this study. Berberine has been studied extensively as an herb-derived resource for treating CRC in ...
Serum triglyceride level is significantly increased in patients with colorectal cancer (CRC), and hypertriglyceridemia is positively correlated with the occurrence of colorectal adenoma [4]. Elevated triglyceride can be a colorectal adenoma risk factor for the potential occurrence and development. Enolase ...
1原发性肿瘤经常可以切除,远处转移的发生显着恶化预后,并常常导致死亡。2,3转移的生物学相关成分被循环肿瘤细胞(CTC),其从肿瘤分离,生存中循环,附着在上皮在靶器官,侵入器官,并最终长大到新的病灶。4虽然CTC的已知是预后相关,5,6,7,8的,9其生物学仅部分地理解为在CRC其极端罕见的结果。10...
(Molecular Devices), and the currents were filtered at 2 kHz and digitized at 10 kHz. Holding potentials were not corrected for the liquid junction potential. Once a GΩ seal was obtained, slight suction was applied to break into whole-cell configuration and the cell was allowed to stabilize...
SS Veiga,VC Zanetti,CRC Franco,... - 《Thrombosis Research》 被引量: 117发表: 2001年 Targeted Deletion of AP-2 α Leads to Disruption in Corneal Epithelial Cell Integrity and Defects in the Corneal Stroma PURPOSE: The present study was undertaken to create a conditional knockout of AP-2alp...
with the increase of the 5-FU loading. Their research study also estimated thein vitroandin vivocytotoxicities of the released 5-FU using HCT-116 (human CRC cells) and female tumour-bearing athymic 6 to 8 weeks old BALB/cnude mice. Together, the cell cycle andapoptosisanalysis were ...