Sequence is 100% murine Murine IgG2 isotype (constant region) Very high ADCP, high ADCC, and high CDC Free from non-relevant mAbs found in hybridoma-based productions Produced in animal-free facilities and defined media Low aggregation < 5% ...
Answer: PA007162.r2a is the recombinant anti-mouse PD-1 monoclonal antibody(重组抗小鼠PD-1单克隆抗体) (rat IgG2a kappa, clone RMP1-14.1) produced in CHO cells or HEK293 cells if needed. It has the same variable region and constant region sequences as the rat anti-mouse PD-1 monoclonal...
Comparisons of this sequence with murine kappa chains already published by other workers bring a confirmation of the large size of the murine Vx chain pool. A complete identity was found with the constant region of the light chain of MOPC 21 from residue 97 to residue 214.Claudine SCHIFF...
Stat1 was phosphorylated by IgG2a and IgG2b stimulation (Fig.4A). Furthermore, the Stat1 protein was phosphorylated only by stimulating the Fc (constant) region of
IgG1, IgG2a and IgG2b share approximately 64-78% amino acid sequence identity within the heavy chain constant region domains (CH1, CH2 and CH3) and may vary in their interaction with complement, NK and mast cells, induction or inhibition by specific cytokines, and ability to cross the ...
InvivoGen provides murine IgG1, murine IgG1e3, and murine IgG2a isotype control mAbs for use with the mouse anti-mouse mAbs. These antibodies comprise the variable region of a mouse monoclonal antibody targeting E. coli β-galactosidase and the constant region of corresponding isotypes. Referenc...
Use in Monkey reported in scientific literature (PMID:33800884). Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (85%). Specificity By immunoelectrophoresis and ELISA this Goat anti-Mouse IgG (H+L) Secondary Antibody [HRP] (Pre-adsorbed) reacts spec...
The pattern of IgG1 and IgG2a subclasses induced in different immunized groups was evaluated. The D and E groups showed a significant increase in IgG1 and IgG2a antibody levels compared to the A, B, and C groups. However, there was no significant variation among the D and E groups. More...
Answer: PA007162.r2a is the recombinant anti-mouse PD-1 monoclonal antibody(重组抗小鼠PD-1单克隆抗体) (rat IgG2a kappa, clone RMP1-14.1) produced in CHO cells or HEK293 cells if needed. It has the same variable region and constant region sequences as the rat anti-mouse PD-1 monoclonal...
Mouse IgG1 antibodies are more like human IgG4 antibodies than human IgG1 antibodies, which behave more like mouse IgG2a or IgG2c antibodies. Many antibody drugs especially those targetting immune checkpoint proteins use the human IgG4 constant regions. ...