are members of the immunoglobulin superfamily and show approximately 28% sequence similarity in their extracellular domains. The two receptor types do not heterodimerize in a receptor complex. Mouse IL-1 RII shares 59% amino acid sequence homology with human IL-1 RII in their extracellular domains...
We reasoned that we could produce Fab′ fragments directly in hybridoma cells by deleting the Fc-coding sequence of the IgH chain. To obtain the Fc portion deletion, we designed gRNAs targeting the DNA proximal to the papain cleavage site of the IgG1 coding sequence. We tested either a ...
The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. Murine IgG1 displays low ADCC and CDC. pFUSE-mIgG1-Fc2additionally features theIL2 signal sequencefor the generation of Fc-Fusion proteins derived...
Dynabeads™ Pan Mouse IgG 结合了您选择用于 特异性细胞分离或去除的单克隆小鼠 IgG。可结合所有的小鼠 IgG 亚类并且具有 Fc 特异性。只需少量 IgG 即可结合。除小鼠外, 所有物种的细胞都可以用本品进行分离,具体取决于 所选特异性抗体。 •去除:细胞可以从样品中清除 ...
mouse IgG1 isotype controls(小鼠IgG1同种型对照) are not from the MOPC-21 hybridoma or its antibody sequences though we also produce and sell the recombinant mouse (MOPC-21) mAb IgG1 isotype control as well as Fc mutants(重组小鼠(MOPC-21)mAb-IgG1同种类型对照以及Fc突变体). Please contact...
抗体亚型:IgG1, kappa 克隆号:P3.6.2.8.1 荧光染料:FITC 产品介绍 技术参数 相关产品 产品介绍 类型: 同型对照 同型对照: 浓度: 0.5 mg/mL 用法: Assay-Dependent(ICC);Assay-Dependent(IF);Assay-Dependent(IHC);Assay-Dependent(Flow) 产品详细信息 ...
The Ser112 nomenclature is based upon the mouse sequence. The analogous phosphorylation site is Ser75 in human and Ser113 in rat. This antibody does not detect Bad phosphorylated at other sites, nor does it detect related family members. Species Reactivity: Human, Mouse, Rat, Monkey...
After genome editing mediated by NHEJ-mediated HITI, the Pigo full-coding cDNA including corrected mutation are inserted in 5'UTR, upstream of mutated exon 1. Blue pentagon, Pigo exon 1 gRNA target sequence in Pigo 5′UTR. Red arrow or black line within blue pentagon, Cas9 cleavage site....
IL-1F10, also known as IL-1HY2, is a secreted protein that shares sequence and structural similarity with IL-1 receptor antagonist and other IL-1 family members. It is expressed in basal epithelia of the skin and in proliferating germinal center CD20+B cells. IL-1F10 binds soluble IL-1...
as proteins (3). LAIR1b, which is the major alternate transcript, lacks most of the ECD. Of the minor transcripts, LAIR1c lacks a signal sequence, and LAIR1d and 1e lack a TM sequence. All mouse splice forms are identical in the last 90 aa of the cytoplasmic domain. LAIR1 shows ...