The long-standing brain atlas published by Paxinos and Franklin was established according to chemoarchitectonic patterns19; it has become the standard reference for the anatomy of the C57BL/6 mouse brain, and was reconstructed into a 3-D atlas20. This atlas is helpful because it covers all ...
Mammalian brain cells show remarkable diversity in gene expression, anatomy and function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly understood. Here we carry out a comprehensive assessment of the epigenomes of mouse brain cell types by applying single-nucleus DNA...
Brain, Mice, Anatomy, Golgi apparatus, AtlasesThe Atlas provides a complete overview of all major structures of the mouse brain that can be identified in Golgi preparations. The most important feature is its three-dimensional integrity since all structures and nerve tracts can be followed from one...
A brain atlas is necessary for analyzing structure and function in neuroimaging research. Although various annotation volumes (AVs) for the mouse brain have been proposed, it is common in magnetic resonance imaging (MRI) of the mouse brain that regions-of-interest (ROIs) for brain structures (no...
Anatomical atlases in standard coordinates are necessary for the interpretation and integration of research findings in a common spatial context. However, the two most-used mouse brain atlases, the Franklin-Paxinos (FP) and the common coordinate framewor
Electronic Atlas of the Developing Human Brain [http://www.ncl.ac.uk/ihg/EADHB] The Edinburgh Mouse Atlas Project [http://genex.hgu.mrc.ac.uk] The Edinburgh Mouse Gene Expression Atlas [http://genex.hgu.mrc.ac.uk] Developmental Gene Expression Map [http://dgemap.org] μMRI Atla...
The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remain poorly understood. Here, we generate a metabolome atlas of the aging wildtype mouse brain f
An anatomic gene expression atlas of the adult mouse brain Studying gene expression provides a powerful means of understanding structure-function relationships in the nervous system. The availability of genome-scal... L Ng,A Bernard,C Lau,... - 《Nature Neuroscience》 被引量: 327发表: 2009年 ...
atlas (freely available onhttp://www.brain-map.org) and report gene expression patterns that both support and challenge established views of brain anatomy. The atlas includes in situ images and 'heat maps' of signal intensity for each gene and brain region on a colorimetric scale. Despite ...
First, 94% of NAP genes have never been previously associated with mouse brain anatomy. Assessment of brain sections usually relies on qualitative evaluation by the human eye, for example, corpus callosum agenesis or hydrocephalus. Our quantitative and ultra-standardized approach allows us to detect ...