Monoclonal antibodies recognising a number of antigens are used in the diagnosis and treatment of ovarian carcinoma. Conventional histology and cytology can be supplemented by immunohistology. Antigens shed from tumours are routinely measured in patients sera by monoclonal based assays to monitor disease...
Ovarian cancer has a high recurrence rate after platinum‐based chemotherapy. To improve the treatment of ovarian cancer and identify ovarian cancer﹕pecific antibodies, we immunized mice with the human ovarian carcinoma cell line, SKOV and generated hybridoma clones. Several rounds of screening ...
Monoclonal antibodies were the first successful targeted anti-cancer therapeutics in the modern era. In the 1970s elucidation of hybridoma and molecular biology technologies established mechanisms to produce and modify monoclonal antibodies with therapeu
Tumors can also be examined for the expression of K1 and OC125 reactivity and thus for the presence of antigens and more specifically, epitopes which react with these two antibodies. (See Tables III and IV below.) K1 reacts, for example, with many ovarian cancers and several other cancers...
In recent years, monoclonal antibodies (mAbs), as potent antitumor tools, have gained increasing importance in the clinic. The use of antibody engineering methods has made it possible for investigators to develop antibody structures with improved antitum
Antibodies are important therapeutic agents for cancer. Recently, it has become clear that antibodies possess several clinically relevant mechanisms of action. Many clinically useful antibodies can manipulate tumour-related signalling. In addition, antibodies exhibit various immunomodulatory properties and, by...
Fendly BM, Winget M, Hudziak RM, Lipari MT, Napier MA, Ullrich A: Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. Cancer Res 50:1550–1558, 1990 Google Scholar Mendelsohn J: Anti-EGF receptor monoclonal ...
Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-... Polypeptide chain initiation factor eIF4GI undergoes caspase-mediated degradation during apoptosis to give characteristic fragments. The most ...
A large number monoclonal antibodies (Mo-Abs) to neoplasms have been utilized as diagnostic tools, but they have not yet been fully characterized from the biological point of view. Antibody-dependent cellular cytotoxicity, complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cyto...
Development of two new monoclonal antibodies reactive to a unique antigenic determinant present on human ovarian cancer cells : S. Ramakrishnan, M. M. Moradi, F.J. Xu, B.Y. Li, Y.H. Yin, S.A. Elg, and L.F. Carson. Department of Pharmacology and Women's Cancer Center, University ...