Monoclonal gammopathy of undetermined significance (MGUS) is much more common than either multiple myeloma or Waldenstrm's macroglobulinemia. Since individuals with MGUS do not need treatment but only monitoring, it is important to distinguish this group from those with progressive plasma cell disorders...
Monoclonal antibodies and cancer therapy : Reisfeld, R.A. and Sell, S. (Eds.), 632 pp. Alan R. Liss, New York, 1985, $78.00, ISBN 0-8451-2626-1doi:10.1016/0022-1759(87)90090-1F. BorekElsevier B.V.Journal of Immunological Methods...
Monoclonal antibodies blocking immune checkpoints have demonstrated unprecedented therapeutic benefits in clinical trials and provided a major breakthrough in oncology19,20,21,22,23. While targeted therapies elicit transient clinical responses because of acquisition of cancer drug resistance usually occurring ...
The Future of Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Itisa privilege to be appointed as Editor-in-Chief (EIC) of Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. The journal has a rich history as one of the earliest—if not the earliest—ournal dedicated to antibodies....
aToday monoclonal antibodies are widely used in cancer therapy. However, clinical experience as well as translational research into antibodies\' pharmacology and effector mechanisms has identified limitations of antibody therapy, including inefficient effector cell recruitment or initiation of complement-depende...
(激素阻滞剂), chemotherapy, andmonoclonal antibodies(单克隆抗体).Hormone receptor-positive(激素受体阳性)cancers are often treated with hormone-blocking therapy over courses of several years. Chemotherapy is predominantly used for case...
Herein, we report the generation of humanized monoclonal antibodies blocking FABP4 activity for breast cancer treatment in mouse models. One clone, named 12G2, which significantly reduced circulating levels of FABP4 and inhibited mammary tumor growth, was selected for further characterization. After co...
30. Fluorescent In Situ Hybridization: Methods and Application in Cancer Diagnosis 31. Cancer Molecular and Functional Imaging 32. Cancer Imaging with Radiolabeled Monoclonal Antibodies 33. Flow Cytometry in Cancer Immunotherapy: Applications, Quality Assurance, and Future 免...
onoclonal antibodies specific for an antigen site associated with (a) the intra-cellular portion of human basal cells and human malignant squamous carcinoma cells, and (b) morphologically normal, non-basal squamous epithelial cells which are pre-cancerous. The method of producing the antibodies. Al...
cells [87]. Interestingly, upregulation of FGL1 expression may also be associated with poor prognosis and anti-PD-1 resistance [87]. Thus, blocking LAG-3 with monoclonal antibodies mitigated the T-cell suppressive immune response triggered by the interaction between LAG-3 and its ligand (Fig....