Monoclonal antibodies do not detect 'breast cancer specific' antigens but, rather, they react with normal or modified tissue antigens which are either preferentially or inappropriately expressed upon malignant cells. Thus far a number of monoclonal antibodies that have a preferential reaction with ...
Herein, we report the generation of humanized monoclonal antibodies blocking FABP4 activity for breast cancer treatment in mouse models. One clone, named 12G2, which significantly reduced circulating levels of FABP4 and inhibited mammary tumor growth, was selected for further characterization. After co...
Eleven murine monoclonal antibodies (MABs) were produced using human mammary cancer (HMC) cell lines as immunogens: None reacted with normal breast tissue, but each had a distinctive pattern of reactivity with HMC and benign proliferative lesions. Two MABs bound to overlapping epitopes of an M(...
Drugs used after and in addition to surgery are calledadjuvant therapy(辅助治疗). Chemotherapy or other types of therapy prior to surgery are calledneoadjuvant therapy(新辅助治疗). There are currently three main groups of medica...
Treating women with early-stage breast cancer with the monoclonal antibody trastuzumab after surgery reduces the risk of cancer recurrence. Treating women diagnosed with one type of early-stage breast cancer with the monoclonal antibody trastuzumab after surgery reduces the risk of the cancer ret...
monoclonal antibodies (mAbs) to block the immunosuppressive molecules and to improve the cytotoxicity of tumor-infiltrating lymphocytes such as CTLA4, PD1, and PD-L1. In addition, ADCs and cancer vaccines have also exhibited the potential to deliver cytotoxic drugs and boost the immune system. ...
Human epidermal growth factor receptor 2–positive (HER2+) breast cancer accounts for ~25% of breast cancer cases. Monoclonal antibodies (mAbs) against HER2 have led to unparalleled clinical benefit for a subset of patients with HER2+ breast cancer. In t
Cancer vaccines and therapeutic monoclonal antibodies Therapeutic monoclonal antibodies can be used to modify tumor cell biology and recapitulate the humoral immune response, or to target critical immunologic checkpoints controlling antitumor immunity. There are emerging data to suggest that humoral immunity ...
围绕该产品，复宏汉霖开展了一系列的头对头比对研究，包括质量对比研究、临床前研究、临床I期和国际多中心临床III期研究等，并于BioDrugs、Cancer Chemotherapy and Pharmacology、欧洲肿瘤内科学会（ESMO）、欧洲乳腺癌大会（EBCC）等国际生物医药领域知名期刊和学术舞台进行发表，充分证明了汉曲优®与原研曲妥珠单抗在...
Immunotherapy has shown promise in many solid tumors including melanoma and non-small cell lung cancer with an evolving role in breast cancer. Immunotherapy encompasses a wide range of therapies including immune checkpoint inhibition, monoclonal antibodies, bispecific antibodies, vaccinations, antibody-drug...