误诊为2型糖尿病的MODY患者的疾病特征 《ProDiGY研究:误诊为2型糖尿病的MODY患者的疾病特征》Diabetes Care,2021年10月 (4) MODY经常被误诊为1型或2型糖尿病。该研究评估了20岁前诊断为2型糖尿病的患者中,MODY的患病率。研究共有3333名参与者,其中93例携带单基因、致病/可疑致病基因突变:16例肝细胞核因子4α...
and reported in the Diabetes issue on (date) concerning a comparison of daily glucose fluctuation between GCK-MODY and type 2 diabetes using continuous glucose monitoring technology. Topics include the differentiation of glucose control patterns between GCK-MODY and type 2 diabetes, the ne...
Maturity-onset diabetes of the young or MODY is considered by many physicians and researchers to be a subset of Type 2 diabetes (T2D) and is often misdiagnosed as T2D.
DiabetesCare:青少年成熟期糖尿病(MODY),不是1型,也不是2型糖尿病! 单基因糖尿病,包括青少年成熟期糖尿病(MODY),是由单一基因异常导致的糖尿病。单基因糖尿病可由破坏葡萄糖感应、胰岛素转录、传递胰岛素释放信号的KATP通道、胰岛素基因或胰腺发育的基因突变引起。正确诊断单基因糖尿病对管理、预测并发症和家族风险都...
HDL-cholesterol: differentiating between HNF-1alpha MODY and type 2 diabetes. Diabet Med. 2003;20(Suppl 2):15.E. Pearson, J. McEneny, I. Young, and A. Hattersley, "HDL- cholesterol: differentiating between HNF-1alpha MODY and type 2 diabetes," Diabetic Medicine, vol. 20, supplement 2...
Home urine C-peptide creatinine ratio (UCPCR) testing can identify type 2 and MODY in pediatric diabetes - Besser, Shields, et al. () Citation Context ...randial C-peptide levels >200 pmol/L (when glucose is >8 mmol/L) or postprandial urinary C-peptide creatinine ratio ≥0.7 nmol/...
In order to gain an understanding of maturity-onset diabetes of youth (MODY), we need to understand the general classification of diabetes mellitus 1,2,3 . Diabetes mellitus is classified as Type 1 diabetes (T1DM), Type 2 diabetes (T2DM)... WE Winter - Springer US 被引量: 86发表: 2003...
MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene expressed by pancreatic acinar cells. MODY8 patients develop childhood-onset exocr
Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2) Biochem. J., 322 (Pt 1) (1997), pp. 57-63 CrossrefView in ScopusGoogle Scholar [41] M. Galan, O. Vincent, I. Roncero, S. Azriel, P....
2.实验及统计方法: 取外周静脉血提取人类基因组DNA。由于线粒体糖尿病是患病率较高的单 基因突变糖尿病,其诊断需要基因分析,故而在进行MODY筛查前,需要先对 其进行排除。采用聚合酶链.限制性片段长度多态(PCR—RFLP)法,首先进行线 粒体基因tRNALEO(o”8’3243A一0位点的检测。14个先证者中未发现线粒体基因...