maturity‐onset diabetes of the young (MODY)ketoacidosisketonuriapolyuriapolydipsiaobesityType 2 diabetes mellitus (T2DM) is a chronic progressive disease with high morbidity and mortality rates. Previously an adult onset disease, it is now being diagnosed more and more in childhood and adolescence. ...
3. Therapeutic approaches in non-insulin treatment for type 2 diabetes mellitus 4. New classes of drugs included in advanced therapy 5. Monotherapy for the treatment of T2DM 5. Combination therapy for treatment of T2DM 7. Novel drug delivery system for antidiabetic drugs for T2DM 8. Conclusion...
Conditions to consider in the differential diagnosis of type 2 diabetes include the following: Atypical diabetes mellitus (ADM) Maturity-onset diabetes of the young (MODY) Diabetes secondary to mutations in mitochondrial deoxyribonucleic acid (DNA) Genetic defects of the beta cell Genetic defects ...
1、糖尿病(diabetes mellitus) 一、概述 v糖尿病是一组以慢性血糖水平增高为特征 的代谢性疾病,是由于胰岛素分泌和作用缺陷所引起。长期碳水化合物以及脂肪、蛋白质代谢紊乱可引起多系统损害,导致眼、肾、神经、心脏、血管等组织器官的慢性进行性损害、功能减退及衰竭。可发生严重代谢紊乱,如糖尿病酮症酸中毒、高渗...
此外,一项跨种族的分子生物学途径分析表明,在所评估的两个种族中,参与年轻人成熟期糖尿病(MODY)发病的途径与2型糖尿病的相关性最强,并且参与胰岛素分泌调节的途径与日本2型糖尿病显著相关14。 Thus, taken together, the pathology of typ...
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovas
B细胞功能遗传性缺陷细胞功能遗传性缺陷:B细胞功能中的单基因缺陷细胞功能中的单基因缺陷,有代表性有代表性的是青年人中的成年发病型糖尿病的是青年人中的成年发病型糖尿病(MODY)。)。其特点:其特点:(1)至少至少5 5年内不需用胰岛素治疗年内不需用胰岛素治疗。 (2) (2) 诊断糖尿病时年龄诊断糖尿病时年龄...
maturity onset diabetes of the young (MODY)peroxisome proliferator activated receptor (PPAR)Type 2 diabetes mellitus is a progressive and complex disorder that is difficult to treat effectively in the long term. The majority of patients are overweight or obese at diagnosis and will be unable to ...
DNA methylation influences gene expression and function in the pathophysiology of type 2 diabetes mellitus (T2DM). Mapping of T2DM-associated DNA methylation could aid early detection and/or therapeutic treatment options for diabetics. A systematic liter
实验动物:MKR小鼠、MODY2小鼠 模型特点:靶向确定基因的小鼠模型,研究分子机制时有优势。 适用研究:II型糖尿病研究 构建方法:自己构建转基因小鼠或直接定制购买。 (3)化学药物诱导(STZ) 实验动物:大鼠 模型特点:链脲佐菌素(Streptozotocin, STZ)诱导胰岛β细胞死亡。