In addition the structural dependence of various pharmacokinetic properties as rate of absorption, distribution, metabolism, and excretion on structural changes in the sulfonamide molecules is quantitatively derived. In contrast to the preconditions for inhibitory activity, changes in lipophilicity play the ...
The combination of non-bacteriostatic amounts of sulfonamide with quantities of either urea or urethane which had no antibacterial action resulted in a mix... L Weinstein,A Mcdonald - 《Journal of Immunology》 被引量: 35发表: 1946年 The Chemotherapy of Intracranial Infections : Observations on ...
Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and ...
Prevalence of Sulfonamide Resistance Genes in Bacterial Isolates from Manured Agricultural Soils and Pig Slurry in the United Kingdom The prevalences of three sulfonamide resistance genes, sul1, sul2, and sul3 and sulfachloropyridazine (SCP) resistance were determined in bacteria isolated... KG Byr...
We found that genes conferring glycopeptide, phenicol, pleuromutilin, bacitracin, sulfonamide and diaminopyrimidine resistance were significantly increased in CSD compared to VD at day 5 after birth (Fig. 4c, Supplementary Fig. 5; FDR-adjusted p < 0.05, Wilcoxon rank-sum test). Interestingly,...
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate 2018, Journal of Medicinal Chemistry Chlorinated Polyfluorinated Ether Sulfonates Exhibit ...
In addition, the risk of the development of resistance and the incidence of certain side effects in the host organism can be assessed, though it is currently possible only to a moderate extent to derive a proposal for a useful combination therapy on the basis of the mode of action of the ...
(SSF-129), 4-bromo-2-cyano-N,N-dimethyl-6-trifluoromethylbenzimidazole-1-sulfonamide, α-[N-(3-chloro-2,6-xylyl)-2-methoxyacetamido]-γ-butyrolactone, 4-chloro-2-cyano-N,N-dimethyl-5-p-tolylimidazole-1-sulfonamide (IKF-916, cyamidazosulfamid), 3-5-dichloro-N-(3-chloro-1-ethyl-1...
Finally, certain of the sulfonamide compounds, such as sulfathiazole, seem capable of stimulating the rate of oxygen consumption of the body tissues, either as a whole or, in some instances, individual tissues. This all suggests that the effect of sulfathiazole on localized infections and on ...
Sulfonamide - production and mode of actionDeuber, RKaeser, PLipscher, J