The aim of the present study was to investigate the mechanism of action of a sulfonamide derivative on glucose uptake in adipose tissue, as well as to characterize the effects of this compound on intestinal disaccharidases and advanced glycation end‐products (AGEs) formation. Camphoryl‐benzene...
Chemical Synthesis: Methanesulfonamide is also used in chemical synthesis for the preparation of different organic compounds. Its purpose in this field involves its reactivity and ability to act as a nucleophile or a source of the sulfonamide functional group. The mechanism of action in chemical synt...
Most compounds with antiviral activity possessing this mechanism of action incorporate in their molecules primary sulfonamide groups. Finally, some small molecule chemokine antagonists acting as HIV entry inhibitors also possess sulfonamide functionalities in their scaffold. 展开 关键词: Sulfonamide, amprenavir...
Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin. Cancer Res 1997; 57: 3208–13. 22 Dittrich C, Dumez H, Calvert H, Hanauske A, Faber M, Wanders J, et al. Phase I and pharmacokinetic study ...
Pharmaceuticals: 4-Chloro-3-pyridinesulfonamide is used in the field of pharmaceuticals. Its purpose in this field may involve its potential as an active pharmaceutical ingredient or as an intermediate in the synthesis of pharmaceutical compounds. The mechanism of action of 4-Chloro-3-pyridinesulfonam...
Hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups (ZBGs), has been investigated as a carbonic anhydrase inhibitor (CAI) by means of kinetic, crystallographic and Raman spectroscopy studies, highlighting interesting results on its mechanism of action. These data can be ...
Inhibitors of human DNA methyltransferases (DNMT) are of increasing interest to develop novel epi-drugs for the treatment of cancer and other diseases. As the number of compounds with reported DNMT inhibition is increasing, molecular docking is shedding light to elucidate their mechanism of action an...
Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects 2023, Biomedicine and Pharmacotherapy Citation Excerpt : Szreder et al. reported that metformin (2 mM) activates AMPK and downregulates TRPC6 expression, leading to the remodeling of the podocyte cytoskeleton and...
Its purpose in this field involves its role as a building block for the synthesis of various compounds. The mechanism of action in pharmaceuticals is dependent on the specific compound being synthesized and its intended therapeutic effect. Polymerization: TERT-BUTYLSULFONAMIDE is also utilized in ...
Its mechanism of action in this field involves its ability to react with other chemicals to form new molecules with desired properties. Ethanesulfonamide has been utilized in the development of drugs and pharmaceutical intermediates. Polymer Industry: This compound finds applications in the polymer ...