up.ConclusionsTheMMTV-PyMTtransgenicmousemodelwaswellkeptandbred,brearttumorscanbe spontaneuosstably.Thiscanbeatypicalanimalmodelforbreastcarcinomaresearch. Keywords:breastcancer;MMTV—PyMTmouse;animalmodel;biologyfeature;pathologychange 收稿日期:2011一O1.12 ...
vWF结果表明乳腺癌有明显的新生血管.结论 乳腺癌MMTV-PyMT转基因小鼠已被成功保种和扩群,可稳定自发性乳腺癌,其生物学特性和病理学改变与人乳腺癌相近,可作为研究乳腺癌发生发展的经典动物模型.%Objective To investigate the biological features of the transgenic mouse model and the pathological changes during ...
Methods: MTT assay was performed to evaluate the growth inhibitory rate of SKBR-3; The MMTV-PyMT transgenic mice model was performed to observe the protection effect in carcinogenesis of JHC in vivo. Results: JHC showed significantly inhibition effect on the prolifera...
tablished.ThedoubletransgenicmiceprovideagoodanimalmodelforfurtherresearchofClC-3intumorgrowthandmetas- tasis. 【Keywords】CLCN3;MMTV-PyMT;Transgenicmice;Breastcancer 中扮演了重要的角色 [1] 。ClC氯通道(ClCchloride channel)是一类电压门控性氯通道,目前在哺乳动 ...
To better define the mechanisms by which RHAMM functions affect metastasis, we assessed the conse- quences of Rhamm-loss to mammary tumor progres- sion using the MMTV-PyMT transgenic mouse model of breast cancer susceptibility [23]. This model was cho- sen for its rapid progression to ...
However, AR protein expression has not been examined in any of the well-established, commonly used transgenic mouse models of breast cancer. The MMTV-PyMT (mouse mammary tumor virus-polyoma middle tumor-antigen) mouse model of breast cancer is widely used and well characterized. MMTV-PyMT mice...
GU81 was tested alone or in combination with doxorubicin for in vivo efficacy in the MMTV-PyMT transgenic model of breast cancer. Results The derivative GU81 has increased in vitro efficacy compared to GU40C4. Single agent therapy (doxorubicin or GU81 alone) had no effect on tumor weight, ...
参考文献 1. Guy CT; Cardiff RD; Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-61.售后服务 相关视频 资料下载 快速...
Specifically, the MMTV-PyMT, Rosa26-RFP-GFP, and Fsp1-Cre triple transgenic mouse model was used to monitor the conversion of RFP-positive epithelial cells to GFP-positive mesenchymal cells in mammary tumors under the control of the ... Z Zhen,X Zhu,K Cui,... - 《Cancer Research》 被...
The highly aggressive nature of the MMTV-PyMT model may be linked with the intrinsically high level of neutrophils in these tumors, similar to the previously observed relationship between increased metastatic potential of these transgenic mice and macrophage infiltration [40,41]. Reflecting this, F4/...