Here, we show that blocking RLIP attenuates the deleterious effects caused by the loss of the tumor suppressor p53 and inhibits the growth of human BC both in vitro and in vivo in MMTV-neu mice. In addition, we show that treatment with the diet-derived, RLIP-targeting chemotherapeutic 2'-...
Ovarian Teratomas in Mice are Derived from Oocytes That Have Completed the First Meiotic Division Spontaneous ovarian teratomas are found in about 50% of strain LT/Sv mice by the time they are 90 days old (Stevens and Varnum 1974). These teratomas resul... JohnJ.Eppig,LeslieP.Kozak,EvaM....
Retrovirus-mediated IL-4 gene therapy in spontaneous adenocarcinomas from MMTV-neu transgenic mice. Gene Ther- apy 6, 1893 A/1897.Sacco M,Benedetti S,Cato EM,et a1.Retrovirus.mediated IL-4 gene therapy in spontaneous adenocarcinorna from MMTV-neutransgenic mice.Gene Therapy. 1999...
mice with human cathepsin G (hCG)-PMLRARα or mammary tumor virus (MMTV)/neu transgenic mice (TM), models of leukemia and breast cancer, respectively... EM Rego,ZG Wang,D Peruzzi,... - 《Journal of Experimental Medicine》 被引量: 355发表: 2001年来源...
Cleary, M.P., et al., Diet-induced obesity and mammary tumor development in MMTV-neu female mice. Nutr Cancer, 2004. 50(2): p. 174–80.Cleary MP, Grande JP, Juneja SC, Maihle NJ. Diet-induced obesity and mammary tumor development in MMTV-neu female mice. Nutr Cancer. 2004;50:...
we have shown that a lack of Muc1 significantly delays tumor progression and/or onset in MMTV-PyV-mT and MMTV-Wnt-1 transgenic mice. Here we show that, unlike the models mentioned above, a loss of Muc1 in MMTV-c-Neu mice (MMTV-c-Neu/Muc1−/−) altered neither mammary tumor onse...
In a recent study, we have shown that in mammary tumors from mice lacking the Cav-1 gene, there are alterations in specific heat shock proteins as well as in tumor development. With this in mind, we have now investigated other proteins in the same mammary mouse tumor model (Her-2/neu ...
A total of 50 uniparous mouse mammary tumor virus (MMTV)-neu and 50 nuliparous MMTV-wnt1 transgenic mice were treated with RARα agonist (retinobenzoic acid, Am580) that was added to the diet for 40 (neu) and 35 weeks (wnt1), respectively. Among the shared antitumor effects was the ...
Combined effects on tumor growth and metastasis by anti-estrogenic and antiangiogenic therapies in MMTV-neu mice. Gene Therapy, 9: 1338-1341.Sacco MG, Soldati S, Mira Cato E, et al (2002). Combined effects on tumor growth and metastasis by anti-estrogenic and antiangiogenic therapies in ...
This experiment was carried out in a mixed genetic background; therefore the controls for each Casp2 À / À /MMTV and Casp2 þ / À /MMTV strain were the Casp2 þ / þ /MMTV littermates of the experimental mice. In the MMTV/c-neu mouse model, multiparous females acquire ...