MMTV-neuRARαRARγWe hypothesized that specific activation of a single retinoic acid receptor-α (RARα), without direct and concurrent activation of RARβ and γ, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer. A total of 50 uniparous mouse mammary tumor ...
Genetic modulation of neu proto-oncogene-induced mammary tumorigenesis. Modulation of oncogene-induced carcinogenesis by secondary mutation or genetic background may be an important factor in determining the expression of the t... GJ Rowse,SR Ritland,SJ Gendler - 《Cancer Research》 被引量: 272发表...
Retrovirus-mediated IL-4 gene therapy in spontaneous adenocarcinomas from MMTV-neu transgenic mice. Gene Ther- apy 6, 1893 A/1897.Sacco M,Benedetti S,Cato EM,et a1.Retrovirus.mediated IL-4 gene therapy in spontaneous adenocarcinorna from MMTV-neutransgenic mice.Gene Therapy. 1999...
Cleary MP, Grande JP, Juneja SC et al (2004) Diet-induced obesity and mammary tumor development in MMTV-neu female mice. Nutr Cancer 50:174-180Cleary MP, Grande JP, Juneja SC, Maihle NJ. Diet-induced obesity and mammary tumor development in MMTV-neu female mice. Nutr Cancer. 2004; ...
Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARα agonist AM580. S, Samuels TA, Mira-y-Lopez R, Farias EF.: Mechanism of inhibition of MMTV-neu and MMTV-Wnt1 induced mammary oncogenesis by RARalpha agonist AM580... Lu,Y.,Bertran,... - 《...
The data obtained in the MMTV-neu model are consistent with a role for Cav-1 in adjacent breast cancer stromal cells in modulating the expression and localization of important proteins implicated in tumor cell behavior.F. Darío Cuello-Carrión...
We thank Drs W Muller and HE Varmus, respectively, for the gift of MMTV-neu and MMTV-wnt1 mice, Dr K Shudo for generous gift of AM580 in amounts sufficient to complete these extensive in vivo studies, and Drs L Ossowski, S Waxman and J Aguirre-Ghiso for helpful advice. This work ...
Here, we show that blocking RLIP attenuates the deleterious effects caused by the loss of the tumor suppressor p53 and inhibits the growth of human BC both in vitro and in vivo in MMTV-neu mice. In addition, we show that treatment with the diet-derived, RLIP-targeting chemotherapeutic 2'-...
Cell surface marker expression in MMTV-Neu ME-CRCs.Francisco, R. SaenzVirginie, OryMaram, AlOtaibySonia, RosenfieldMary, FurlongLuciane, R. CavalliMichael, D. JohnsonXuefeng, LiuRichard, SchlegelAnton, Wellstein
Systemic gene therapy with anti-angiogenic factor inhibits spontaneous breast tumor growth and metastasis in MMTV neutransgenic mice[J].Gene Therapy,2001,(01):67-70.doi:10.1038/sj.gt.3301358.Sacco MG,Cato EM,Ceru R,et al.Systemic gene therapy with anti—angiogenic factor inhibits spontaneous ...