关键词:乳腺癌;MMTV.PyMT转基因小鼠;动物模型;生物学特征;病理学改变 中图分类号:R737.9;R965.1 文献标识码:A doi:10.3969/j.issn.1006—8783.2011.02.019 文章编号:1006.8783(2011)02—0178.05 ThebiologicalandpathologicalfeaturesofthebreastcancermousemodelMMTV- ...
The MMTV-PyMT (mouse mammary tumor virus-polyoma middle tumor-antigen) mouse model of breast cancer is widely used and well characterized. MMTV-PyMT mice develop spontaneous mammary tumors that closely resemble the progression and morphology of human breast cancers [12–14]. MMTV-PyMT tumors lose...
Cancer stem cells are the seeds of tumor growth, but there are limited cell-based methods that exist to study the properties of these cells. To create a model of breast cancer stem cells, we isolated tumors from MMTV-PyMT mice. Two out of the four different cell types isolated survived ...
These data suggest that the MMTV-PyMT model and Met-1 cells may serve as valuable tools for mechanistic studies of the role of AR in disease progression and how anti-androgens affect the tumor microenvironment. 展开 关键词: Breast Cancer Androgen Receptor Enzalutamide Androgen Receptor Expression ...
vWF结果表明乳腺癌有明显的新生血管.结论 乳腺癌MMTV-PyMT转基因小鼠已被成功保种和扩群,可稳定自发性乳腺癌,其生物学特性和病理学改变与人乳腺癌相近,可作为研究乳腺癌发生发展的经典动物模型.%Objective To investigate the biological features of the transgenic mouse model and the pathological changes during ...
To improve diagnosis and drug development, it is critical to identify panels of genes and molecular pathways involved in tumor progression and malignant transition. Using the PyMT mouse, a genetically engineered mouse model that has been widely used to study human breast cancer, we profiled and ...
Origin and progression of pregnancy-dependent mammary tumors induced by new mouse mammary tumor virus variants. Breast Cancer Res Treat. 2002;75:191–202. doi:10.1023/A:1019932516887. Article PubMed CAS Google Scholar Gattelli A, Cirio MC, Quaglino A, Schere-Levy C, Martinez N, Binaghi M,...
sionsTransgenicmousemodelsofspontaneousbreastcancerwithsimultaneouslyoverexpressingClC3aresuccessfullyes tablished.ThedoubletransgenicmiceprovideagoodanimalmodelforfurtherresearchofClC3intumorgrowthandmetas tasis. 【Keywords】CLCN3;MMTVPyMT;Transgenicmice;Breastcancer ...
METHODS: We have intercrossed Mmp8-null mice with the Polyoma virus middle T oncogene-driven (MMTV-PyMT) mouse model of mammary cancer to explore the... J Decock,W Hendrickx,S Thirkettle,... - 《Breast Cancer Research》 被引量: 16发表: 2015年 Transcriptomic analysis of MMP8 effects on...
Biomarkers of Residual Disease, Disseminated Tumor Cells, and Metastases in the MMTV-PyMT Breast Cancer Model DOI: 10.1371/journal.pone.0058183 Christian Franci, Jenny Zhou, Zhaoshi Jiang, Zora Modrusan, Zinaida Good, Erica Jackson, Hosein Kouros-Mehr Full-Text Cite this paper Add to My Lib ...