作者发现FOXM1上调可激活WNT/β-catenin信号通路,与β-catenin结合,抑制β-catenin的降解,从而促进MLL-r AML(在婴儿中发生率占70%,在AML中占10%)LSC的自我更新。且MLL-AF9 AML病人的LSC对FOXM1抑制剂敏感,而正常的造血干细胞HSC对FOXM1抑制剂...
Acute myeloid leukemia (AML) with 11q23/rearrangement (MLL-r AML) is allocated to the intermediate- or high-risk cytogenetic prognostic category depending on thefusion partner. A more favorable outcome has been reported in patients receiving an allogeneic hematopoietic stem-cell transplantation (allo...
使用VTP50469鼠粮处理后,所有检测组织中小鼠MLL-AF9 AML细胞均被清除,从而证实VTP50469对消除小鼠MLL-AF9驱动的AML是有效的,并且在小鼠粮中较长的时间都是稳定的。用MLL-r AML PDXs移植物和VTP50469处理的小鼠,与喂食对照饲料的小鼠相比,PB中的人CD45+(hCD45+)...
使用VTP50469鼠粮处理后,所有检测组织中小鼠MLL-AF9 AML细胞均被清除,从而证实VTP50469对消除小鼠MLL-AF9驱动的AML是有效的,并且在小鼠粮中较长的时间都是稳定的。用MLL-r AML PDXs移植物和VTP50469处理的小鼠,与喂食对照饲料的小鼠相比,PB中的人CD45+(hCD45+)细胞显著减少。此外,VTP50469处理小鼠的外周血中...
结果 MLL-r 成人急性白血病诊断时常表现为外周血白细胞异常升高、贫血和血小板减少，诊断时中位白细胞计数为46.83（8.13 ， 99.93）×109/L 。MLL-r B-ALL 最常见的重排为MLL-AF4重排；MLL-r AML 最常见重排为MLL-AF9和MLL-AF6重排。单纯化疗复发率高，异基因造血干细胞移植可以显著改善患者预后（P <...
menin,一种普遍表达的由1型多发性内分泌瘤形成(men1)肿瘤抑制基因编码的核蛋白,具有与mll融合蛋白的高亲和力结合相互作用且为致癌mll-r融合蛋白的基本辅因子。这种相互作用的破坏导致体外和体内mll-r白血病细胞的选择性生长抑制和细胞凋亡。 2、menin-mll复合物在去势抵抗性/晚期前列腺癌中起作用,并且已展示出men...
Outcome of Allogeneic Hematopoietic Stem-Cell Transplantation for Acute Myeloid Leukemia (AML) with 11q23 (MLL) Rearrangement (MLL-r AML). A Retrospective ... Outcome of Allogeneic Hematopoietic Stem-Cell Transplantation for Acute Myeloid Leukemia (AML) with 11q23 (MLL) Rearrangement (MLL-r AML...
[92],BCORandIDH1in AML[93],MLL2in diffuse large B-cell lymphoma (DLBCL)[94], andNOTCH1in mantle cell lymphoma (MCL)[95]. Different international consortia have been initiated to comprehensively characterize the mutational landscape of different cancers. Most notable, the Cancer Genome Atlas (...
The remaining 17 MLL‐r cases exhibited complex translocations with homozygous disruptions on chromosome 11 or two breakpoints on the same MLL allele with a deletion of functional regions. A total of 77 patients (45 ALL and 32 AML) received chemotherapy with a median follow 槻2.5 years. ...
Selective silencing of the NPM1 mutant protein and apoptosis induction upon ATRA in vitro treatment of AML cells carrying NPM1 mutations. Blood 2007; 110: 868. 36 Balusu R, Fiskus W, Rao R, Chong DG, Nalluri S, Mudunuru U et al. Targeting levels or oligomerization of nucleophosmin 1 ...