Signs and symptoms of mixed connective tissue disease can include rash, muscle pain, joint pain, swollen fingers, swollen hands, and malaise. Other associated symptoms and signs can include low-grade fever and Raynaud's phenomenon (sensitivity, numbness, and loss of color in the fingers, toes,...
Mixed connective tissue disease (MCTD) is a systemic autoimmune disease with features overlapping multiple autoimmune disorders. One study found that over 55% of patients with MCTD experienced neuropsychiatric symptoms, the most common of which was an "aseptic meningitis-like syndrome." We present a ...
Mixed connective tissue disease (MCTD), or: Sharp syndrome, is an uncommon, specifically defined, overlap syndrome. MCTD should be suspected when additional overlapping features are present in patients appearing to have rheumatoid arthritis, SLE, scleroderma, or polymyositis. MCTD is characterised...
Mixed connective tissue disease (MCTD) is a systemic inflammatory disease affecting connective tissue with the underlying autoimmunological mechanism. The core of MCTD is an appearance of symptoms of several other inflammatory diseases of connective tissue – systemic lupus erythematosus, systemic scleroderma...
(g) Mixed Connective Tissue Disease, also known as Sharp's Syndrome, (20) commonly abbreviated as MCTD is an autoimmune disease in which the body's defence system attacks itself. Primary and secondary Raynauds, and how to help improve the symptoms of both with acupuncture, and auricular acupu...
Signs and symptoms in the masticatory system in ten patients with mixed connective tissue disease. Scand J Rheumatol 1990; 19:363-373.Konttinen YT, Tuominen TS, Piirainen HI, Kononen MH, Wolf JE, Hietanen JH, et al. Signs and symptoms in the masticatory system in ten patients with mixed...
Mixed connective tissue disease (MCTD) was first recognized by Sharp and Colleagues in 1972 among a group of patients with overlapping clinical features of systemic lupus erythematosis (SLE), scleroderma and myositis, with the presence of distinctive antibodies against, what now is known to be U1...
The case in question of the Sharp-syndrome is a mixed collagenosis with symptoms of sclerodermia, Erythematodes visceralis, dermatomyositis and rheumatoid arthritis. Apart from the clinical symptomatology the immunological profile is decisive for the ascertainment of the diagnosis. With the help of 3...
Esophageal symptoms in mixed connective tissue disease (MCTD) have been investigated radiologically. We investigated the esophageal lesions in MCTD histopathologically, and analyzed relationships between these lesions and autoantibodies extracted from the serum of MCTD patients. Esophageal tissues from 27 MCT...
All six patients had symptoms or laboratory values sug- gestive of myositis indistinguishable from childhood dermatomyo- sitis. All patients had Raynauf's phenomenon. Four patients were suspected of having nephritis based on hematuria andlor pro- teinuria; this was confirmed in two patients by ...