Muscle mitochondrial energetics predicts mobility decline in well-functioning older adults: the Baltimore Longitudinal Study of Aging. Aging Cell 21, e13552 (2022). CAS PubMed PubMed Central Google Scholar Gouspillou, G. et al. Increased sensitivity to mitochondrial permeability transition and myo...
Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer’s disease (AD). The molecular mechanisms of impaired mitochondrial homeostasis in AD are being investigated. Here we provide evidence that mitophagy is impaired in the hippocampus of AD pa...
However, the cellular and molecular underpinnings of mitochondrial mass homeostasis remain obscure. In our recent study, we demonstrate that DCT-1, the Caenorhabditis elegans homolog of mammalian BNIP3 and BNIP3L/NIX, is a key mediator of mitophagy promoting longevity under stress. DCT-1 acts ...
aging lifespan mitochondria mitochondrial autophagy mitochondrial biogenesis mitophagy Introduction “Art is the elimination of the unnecessary” (Picasso), and by analogy, so is mitophagy for the mitochondrial network. Healthy mitochondria are essential for many fundamental processes in aerobic cells, includ...
Retinal ganglion cells (RGCs) with complex dendrites and significantly longer axonal structures have relatively higher energy requirements. Furthermore, mitochondria are involved in various physiological processes in RGCs, such as maintaining metabolic balance, regulating intracellular calcium levels, ...
These observations not only support a key role for mitochondrial dysfunction in aging and PD etiology but provide a model in which future therapeutics could be tested. However, given the complexity of PD pathophysiology, it may be unrealistic to expect one in vivo model to accurately recapitulate ...
3. Mitophagy in Aging Mitochondria are the energy center of cells. Mitochondrial maintenance is a prerequisite for the homeostasis of cells and organisms. The equilibrium between mitochondrial biogenesis and mitochondrial removal is crucial for a healthy system. Several studies focused on the evidence th...
The accumulation of dysfunctional mitochondria with time contributes to the aging process likely due to accumulation of reactive oxygen species (ROS)-induced mtDNA mutations in line with the ‘free radical theory of aging’ since mouse life span can be increased and age-related phenotypes can be am...
Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve and declining oocyte quality. However, as an important contributing factor, the role of metabolic regulation during reproductive aging is poorly understood. Here,
healthy aging and longevity12,15,16,17. Interestingly, genetic and/or pharmacological upregulation of intracellular NAD+levels protects against obesity and type 2 diabetes in rodents14,18,19,20, and against age-related diseases and neurodegenerative diseases such as Alzheimer’s disease16,17,21,22...