Mitochondrial DNA copy number and disease.A study ineLifeidentifies 71 nuclear loci associated with mitochondrial DNA copy number (mtDNA-CN) and reveals a putative causal role for mtDNA-CN in dementia.doi:10.1038/s41576-022-00451-2Dorothy Clyde...
However, emerging evidence strongly suggests that the proportion of mutated mtDNA copies is not the only determinant of disease but that also the absolute copy number matters. In this review, we critically discuss current knowledge of the role of mtDNA copy number regulation in various types of ...
Mitochondrial pathology has been implicated in the pathogenesis of psychotic disorders. A few studies have proposed reduced leukocyte mitochondrial DNA (mtDNA) copy number in schizophrenia and bipolar disorder type I, compared to healthy controls. However, it is unknown if mtDNA copy number alteration ...
mtDNA copy number in leukocyte DNA has also been linked to several other cancers, although the temporal relationship between mtDNA and cancer has not been adequately explored.Using a nested case-control study design, we examined the association between mtDNA copy number in 162 gastric cancer cases ...
Mitochondrial DNA Copy Number and Pancreatic Cancer in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study 来自 学术范 喜欢 0 阅读量: 18 作者: Shannon M. Lynch,Stephanie J. Weinstein,Jarmo Virtamo,Qing Lan,Chin-San Liu,Wen-Ling Cheng,Nathaniel Rothman,Demetrius Albanes,Rachael Z. ...
Mitochondrial DNA Copy Number and Pancreatic Cancer in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Diabetes, obesity, and cigarette smoke, consistent risk factors for pancreatic cancer, are sources of oxidative stress in humans that could cause mitochond... SM Lynch,SJ Weinstein,J Virt...
A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma. There was a dose-response relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; ... Qing,Lan,Unhee,... - 《Blood》 被引量: 162发...
The present results showed that patients with MDD had a higher mtDNA copy number and a decreased DNA methylation status in the PGC1α promoter. mtDNA copy numbers were negatively associated with an age, psychomotor agitation, and somatic symptoms in MDD. These results suggest that the alterations...
et al. Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations. Epigenomics 10, 1431–1443 (2018). Article CAS PubMed Google Scholar Blanch, M., Mosquera, J. L., Ansoleaga, B., Ferrer, I. & Barrachina, M. Altered ...
Mitochondrial DNA (mtDNA) copy number in leukocytes has been regarded as a biomarker for various environmental exposures and chronic diseases. Our previous study showed that certain demographic factors (e.g. age, gender, BMI, etc.) significantly affect levels of leukocyte mtDNA copy number in Mexic...