Using data of the current prevalence of autism as 200:10,000 and a 1:2000 incidence of definite mitochondrial (mt) disease, if there was no linkage of autism spectrum disorder (ASD) and mt disease, it would be expected that 1 in 110 subjects with mt disease would have ASD and 1 in ...
Using data of the current prevalence of autism as 200:10,000 and a 1:2000 incidence of definite mitochondrial (mt) disease, if there was no linkage of autism spectrum disorder (ASD) and mt disease, it would be expected that 1 in 110 subjects with mt disease would have ASD and 1 in ...
MD was once thought to be uncommon but is now considered the most recognized cause of metabolic disease.30Despite increased recognition, the prevalence of MD is probably underestimated.46The minimum birth prevalence of an ETC defect with onset at any age has been estimated at 1 in 7634 individua...
Second, characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease (MD) were compared with published literature of two general populations: ASD children without MD, and non-ASD children with MD. The prevalence of MD in the general population of ASD was ...
The ketogenic diet (KD) is a therapeutic dietary approach that has been used clinically for several decades to manage symptoms of various diseases, such as epilepsy, autism spectrum disorder, and diabetes.152,153,154The KD works by reducing carbohydrate intake and promoting FAO. The process of ...
Autism spectrum disorder (ASD) has been associated with mitochondrial disease (MD). Interestingly, most individuals with ASD and MD do not have a specific genetic mutation to explain the MD, raising the possibility of that MD may be acquired, at least in a subgroup of children with ASD. Acqu...
The prevalence of classic mitochondrial disease in the ASD population was estimated to be about 5.0%; however, evidence indicates that about 50% of children with ASD may experience metabolic abnormalities resulting from impaired function of mitochondria. Recently, studies have shown interactions between ...
Developmental Disabilities Monitoring Network Surveillance Year Principal I, Centers for Disease C, Prevention. Prevalence of autism spectrum disorder among children aged 8 years — autism and developmental disabilities monitoring network, 11 sites, United States, 2010 MMWR Surveill Summ, 63 (2014), pp...
endocrine and gastrointestinal systems. The phenotypes of PMD are on a spectrum ranging from prenatal or neonatal onset lethal disease affecting multiple organ systems to adult onset progressive external ophthalmoplegia. The disease onset is in childhood in two-thirds of the individuals with PMD [9,...
In mild cases, individuals with PA often remain metabolically stable, but may instead experience learning disabilities and autism spectrum disorder, in addition to dilated cardiomyopathy and chronic kidney disease [1,2,3,4,5]. The estimated birth incidence of PA varies by region, ranging 1:1000...