L. and Natowicz M. R. ( 2008 ) Mitochondrial disease in autism spectrum disorder patients: a cohort analysis . PLoS ONE 3 , e3815.Weissman J. R., Kelley R. I., Bauman M. L., Cohen B. H., Murray K. F., Mitchell R. L., et al. (2008). Mitochondrial disease in autism ...
Accumulating data show abnormalities in mitochondrial function both in the brain and peripheral tissues of individuals with ASD, strongly suggesting possible links between abnormalities in mitochondrial function and ASD. The prevalence of classic mitochondrial disease in the ASD population was estimated to ...
DNA, MitochondrialCase-Control StudiesAutistic DisorderPhosphorylationHydrogen PeroxideUsing data of the current prevalence of autism as 200:10,000 and a 1:... A Legido,R Jethva,MJ Goldenthal - 《Seminars in Pediatric Neurology》 被引量: 92发表: 2013年 Autism: A Systems Biology Disease Autism is...
inflammatory bowel disease, food intolerance, and/or failure to thrive. Several categories of inborn-errors of metabolism have been observed in some patients with autism including mitochondrial disorders, disorders of creatine metabolism, selected amino acid disorders, disorders of folate or B12 metabolism...
Nuclear and mitochondrial genome defects in autisms. Ann N Y Acad Sci 2009; 1151: 102–132. Article CAS PubMed Google Scholar Hass RH . Autism and mitochondrial disease. Dev Disabil Res Rev 2010; 16: 144–153. Article Google Scholar Baieli S, Pavone L, Meli C, Fiumara A, Coleman ...
Autism spectrum disorders (ASDs) are neurodevelopmental disorders that cause behavioral, social, and communication impairments. Several lines of evidence from biochemical, anatomical, and neuroradiographical studies suggest impairment of energy metabolism and mitochondrial dysfunction in ASDs. Mitochondrial electr...
characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease (MD) were compared with published literature of two general populations: ASD children without MD, and non-ASD children with MD. The prevalence of MD in the general population of ASD was 5.0% (95...
Mitochondrial diseaseThe purpose of this study is to define correlations between indices of brain dysfunction, such as functional MRI (fMRI) and neuropsychological testing abnormalities, with oxidative phosphorylation (OXPHOS) defects in children with autistic spectrum disorders (ASD). This study is an ...
The etiology is generally multifactorial, including genetic, immunological and/or environmental factors. A group of ASD has been linked to mitochondrial dysfunction with subsequent deficiency in energy production. Patients with ASD and mitochondrial disease often show signs and symptoms uncommon to ...
Autism spectrum disorder (ASD) has been associated with mitochondrial disease (MD). Interestingly, most individuals with ASD and MD do not have a specific genetic mutation to explain the MD, raising the possibility of that MD may be acquired, at least in a subgroup of children with ASD. ...