Mitochondrial disease in autism spectrum disorder patients: a cohort analysis . PLoS ONE , 3 , e3815 .Weissman, JR, Kelley, RI, Bauman, ML, Cohen, BH, Murray, KF, Mitchell, RL, Kern, RL, Natowicz, MR (2008) Mitochondrial disease in autism spectrum disorder patients: a cohort analysis....
CamKinase II activity has been proposed to be a mechanism associated with regulating repetitive, involuntary, and obsessive behaviors in psychiatric disease100, suggesting that BT could have a potential role in modulating these ASD-associated behaviors. Connection with patients with autism There are ...
Herein, we review the mechanism of mitochondrial dynamics, and its impacts on cellular function. We also delve into the changes that occur in mitochondrial dynamics during health and disease, and offer novel perspectives on how to target the modulation of mitochondrial dynamics....
Table 1. Metabolic disorders associated with epilepsy and autism spectrum disorder. DisorderClinical featuresDiagnostic testing Disorders of energy metabolism Mitochondrial disease Developmental regression , gross motor delay, fatigability, ataxia, and gastrointestinal abnormalities • Fasting serum lactate, pyru...
“Mitochondrial dysfunction doesn’t really cause anything, what it does is predisposes towards seemingly everything. It’s one of many risk factors in multifactorial disease. It can predispose towards epilepsy, chronic fatigue, and even autism, but it doesn’t do it alone. It does it in combi...
HIF-1α: Hypoxia-Inducible-Factor HIF-1α COX: Cytochrome C oxidase MAM: Mitochondria-associated ER membrane TSC: Tuberous sclerosis complex PCP: Planar cell polarity ASD: Autism spectrum disorders DS: Down syndrome AD: Alzheimer disease PD: Parkinson’s disease ...
The ketogenic diet (KD) is a therapeutic dietary approach that has been used clinically for several decades to manage symptoms of various diseases, such as epilepsy, autism spectrum disorder, and diabetes.152,153,154The KD works by reducing carbohydrate intake and promoting FAO. The process of ...
Diabetic kidney disease (DKD), has become the main cause of end-stage renal disease (ESRD) worldwide. Lately, it has been shown that the onset and advancement of DKD are linked to imbalances of gut microbiota and the abnormal generation of microbial metabolites. Similarly, a body of recent ...
Whereas PPA is an energy substrate and has many proposed beneficial effects, it is also associated with human disorders involving mitochondrial dysfunction, including propionic acidemia and autism spectrum disorders (ASDs). We aimed to investigate the dichotomy between the health and disease effects of ...
CI deficiency is also found in patients with Parkinson disease, autism, and diabetes (18, 19, 20). Mitochondrial dysfunction has been proposed to lead to type 2 diabetes and obesity, which causes insulin resistance in skeletal muscle and adipose tissue (21, 22). An inverse correlation between...