Host mitochondria influence gut microbiome diversity: A role for ROS.doi:10.1126/SCISIGNAL.AAW3159Tal YardeniCeylan E. TanesKyle BittingerLisa M. MatteiPatrick M. SchaeferLarry N. SinghGary D. WuDeborah G. MurdockDouglas C. WallaceAmerican Association for the Advancement of Science...
Marvin Edeas, University Paris Descartes, INSERM U1016, France Host mitochondria influence gut microbiome diversity: A role for ROS Tal Yardeni,Children's Hospital of Philadelphia,USA Summary of Dr. Yardeni's presentation: "Changes in the gut microbiome are linked with the same diseases as t...
John G. Geisler, Mitochon Pharmaceuticals, Inc, USA Host mitochondria influence gut microbiome diversity: A role for ROSTal Yardeni, Children's Hospital of Philadelphia, USA The cellular stress protein MNRR1/CHCHD2 and mitochondrial diseaseLawrence Grossman, Wayne State University, USA Mitochondria-...
many mutations in ETC complex I components lead to increased levels of ROS, conferring an increased metastatic propensity.10,11Notably, mutations in ND4 (C12084T) and ND5 (A13966G) in the MDA-MB-231 breast cancer cell line12and missense and nonsense mutations in ND6 in the A549...
Gruber J, Kennedy BK (2017) Microbiome and longevity: gut microbes send signals to host mitochondria. Cell 169:1168-1169J. Gruber, B.K. Kennedy, ... Jan,Gruber,Brian,... - 《Cell》 被引量: 9发表: 2017年 56 THE VIABILITY AND LONGEVITY OF OGYE CHICKEN FROZEN SEMEN WITH MITOTEMPOL,...
Mitochondria are not only the main energy source in the hepatocytes but also play a major role in the cell redox homeostasis and maintain normal liver function including signalling pathways and the metabolism of exogenous substances. These roles assign mitochondria a gateway function in protecting hepat...
[37]. The continuous production of toxic mediators such as reactive oxygen species (ROS) and cytokines inhibit and destroys mitochondria [38,39]. A growing body of evidence indicates that inflammation may further cause deleterious changes in mitochondrial function, affecting oxidative phosphorylation and...
Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria and is hence an essential process contributing to mitochondrial quality control. PTEN-induced kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin are critical molecu
Among the metabolites of ellagitannins that are produced in the gut microbiome, urolithin A has received an increasing amount of attention as a novel candidate with anti-oxidative and neuroprotective effects in AD. Here, we investigated the effect of urolithin A on high glucose-induced amyloido...
to NAFLD include the environment, gut microbiome, deranged glucose-lipid metabolic pathways, metabolic inflammation primarily mediated by innate immune signaling, adipocytokine impairment (e.g., tumor necrosis factor (TNF)-α, adiponectin, resistin, leptin, angiotensin II), and comorbidities [2,3,4]...