Crude measures of β-oxidation were initially performed in skeletal muscle homogenates prepared from red and white quadriceps femoris. As expected, oxidation rates of [14C]oleate were several-fold higher in mitochondria-enriched red skeletal muscle (Figures 4A and 4B). The 12-week HF diet did ...
3, in addition to SIRT1-mediated improvements in nuclear-mitochondrial communication, NAD+ is transported into mitochondria and extensively modulates mtDNA stability, membrane dynamics, mitophagy, and the mitochondrial unfolded protein response (UPRmt), which are common features of ageing skeletal muscle....
Carnitine palmitoyltransferase-1 (CPT1) is an enzyme located on the outer mitochondrial membrane that transports long-chain fatty acids into mitochondria for β-oxidation, thus controlling the rate of mitochondrial fatty acid oxidation (FAO). We recently described knockout mouse model with skeletal mu...
Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen Species via a Mitochondria-Mediated Apoptosis Pathway Astaxanthin (AX) is a carotenoid that exerts potent antioxidant activity and acts in the lipid bilayer. This study aimed to investigate the effects of AX ...
Gut microbiota is very important for energy metabolism and regulation, which in turn affect the health and physiological functions of the host, and provide energy required for exercise. Supplementation with probiotics may be one of the ways to change the
mitochondria, ubiquitin–proteasome system, and autophagy. In this review, we highlighted the underlying mechanisms of skeletal muscle mass loss including Notch signaling, Wnt/β-catenin signaling, Hedgehog signaling, AMP-activated protein kinase (AMPK) signaling, and mammalian target of rapamycin (mTOR...
happen to be one of them, there are many papers out there that it improves mitophagy which is the health of mitochondria the turnover of mitochondria helps with the renewal of mitochondria, but what's so fascinating is there are trials in human individuals that it increases strength and ...
In general, the imbalance of division and fusion leads to abnormal mitochondrial function ( Wei and Ruvkun, 2020 ). Mitofusin 1 (Mfn1), mitofusin 2 (Mfn2) and mitochondrial dynamin like GTPase (OPA1) contribute to mitochondrial docking and fusion, and stabilize associations between mitochondria (...
TORC2 complex, which contains Rictor (Fig.1). Genetic approaches identified different functions for these two complexes. While mTORC2 is related to glucose and lipids homeostasis5, mTORC1 regulates several anabolic processes, including protein synthesis, ribosome, and mitochondria biogenesis. While ...
282 Similarly, myoblasts treated with palmitic acid, the most common saturated fatty acid found in the human body, show inhibited proliferation and myogenic differentiation as well as increased mitochondrial ROS levels and mitochondria-mediated apoptosis,285 while effective muscle regeneration requires ...