Cardiovascular disease (CVD) remains a global economic burden even in the 21st century with 85% of deaths resulting from heart attacks. Despite efforts in reducing the risk factors, and enhancing pharmacotherapeutic strategies, challenges persist in early identification of disease progression and function...
By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via ...
Ferroptosis is a regulatory cell death process pivotal in myocardial ischemia–reperfusion (I/R) injury. However, the precise mechanism underlying myocardial ferroptosis remains less known. In this study, we investigated the pathophysiological mechanisms
During heart development, the mitochondrial system is dynamically regulated to support ATP synthesis, energy transduction, and cell signaling events (Fig.2). The increase in mitochondrial mass in the growing heart is accompanied by structural differentiation into interfibrillar (IFM) and subsarcolemmal ...
Ch 22. The Cardiovascular System Ch 23. The Blood Vessels Ch 24. The Digestive System Ch 25. The Urinary & Endocrine Systems Ch 26. The Brain & Nervous System Ch 27. The Muscular System Ch 28. The Skeletal System & Connective... Ch 29. Sight, Hearing & Other Senses Ch 30. Health ...
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal... Yeong-Renn,Chen,L Jay,... - 《Circulation Research》 被引量: 360发表: 2014年 Mitochondria and reactive oxygen species. Free Radic Biol ...
Beriberi and the Cardiovascular System In the early stages of beriberi the patient will have palpitations of the heart on physical or mental exertion. In later stages, palpitations and breathlessness will occur even at rest. X-ray examination shows the heart to be enlarged and changes in the ...
Thousands to millions of cells are shed from a neoplasm into the circulation every day, but the majority do not survive or result in a metastatic outgrowth.1,2Disseminated cells are under extreme stress (from shear forces, the immune system, reactive oxygen species (ROS), nutrient deficiency, ...
Any mutation in this genome might impair the mitochondrial function leading to increased oxidative stress, inflammation, and cell death, which are deleterious factors to cardiovascular system. There is a growing body of evidence in support of the roles of mitochondrial genome mutations in the ...
cardiovascular, and metabolic diseases. Due to their irreplaceable roles and incompletely characterized mechanisms, mitochondria have garnered increased interest in recent decades, especially in the last five years, in which more than 10,000 research papers have been published annually and in which novel...