Abnormal retention of mitochondria in mature red blood cells (RBC) has been recently reported in sickle cell anemia (SCA) but their functionality and their role in the pathophysiology of SCA remain unknown. The presence of mitochondria within RBC was determined by flow cytometry in 61 SCA ...
In erythrocytes mitochondria exhibited a canonical, functional respiratory chain. The content and activity of cytochromes in erythrocytes were, however, significantly lower as compared to mammalian tissues. 展开 关键词: Torpedo Red-blood cells Mitochondria Erythroblasts Respiratory chain Cytochromes ...
Molecular mechanisms of the crosstalk between mitochondria and nadph oxidase through reactive oxygen species - studies in white blood cells and in animal ... S S.,S S.,W P.,... - 《Vascular Pharmacology》 被引量: 125发表: 2012年 Causes and consequences of mitochondrial reactive oxygen specie...
A. et al. A network of macrophages supports mitochondrial homeostasis in the heart. Cell 183, 94–109 (2020). Article CAS PubMed Google Scholar Al Amir Dache, Z. et al. Blood contains circulating cell-free respiratory competent mitochondria. FASEB J. 34, 3616–3630 (2020). Article CAS ...
A spherical or elongated organelle in the cytoplasm of nearly all eukaryotic cells, containing genetic material and many enzymes important for cell metabolism, including those responsible for the conversion of food to usable energy. [New Latin : Greekmitos,warp thread+ Greekkhondrion, diminutive of...
Overexpression of mitochondrial Hsp70|[sol]|Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia Journal of Cerebral Blood Flow & Metabolism stands at the interface between basic and clinical neurovascular research, and features research on experimenta......
Metastasis begins with cells acquiring the ability to invade surrounding stroma and enter the vasculature, lymphatics or coelomic cavity (a). In haematogenous metastasis, cells disseminate widely while interacting with other blood-borne cells and plasma components as well as with endothelial cells linin...
To label mitochondria, live cells are simply incubated with the MitoTracker probe of your choice. The mitochondrial staining dyes passively diffuse across the plasma membrane and accumulate in active mitochondria. The MitoTracker dyes are offered in a range of wavelengths and can be used for ...
and tissue breakdown (necrosis), which release the contents of cells, including broken mitochondria. Because each cell contains dozens of mitochondria and there are thousands of cells within our tissues, severe trauma can result in the release of large amounts of mitochondrial DAMPs into the blood...
and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo app...