Margreiter, Mitochondria in the Cold, in: G. Heldmaier, M. Klingenspor (Eds.), Life in the Cold, Springer-Verlag, Berlin, Hiedelbegr, New York, 2000, pp. 431- 442.Nicholls DG, Ferguson SJ. Mitochondria in the cell. In: Bioenergetics 3. Barcelona, Spain: Academic Press; 2002:249-...
In a study, published today in theEMBO Journaland led by Dr João Passos at Newcastle University, they found that when mitochondria were eliminated from ageing cells they became much more similar to younger cells. This experiment was able for the first time to conclusively prove that mitochondri...
Viruses need cells for their replication and, therefore, ways to hijack cellular functions. Mitochondria play fundamental roles within the cell in metabolism, immunity and regulation of homeostasis due to which some viruses aim to alter mitochondrial functions. Herein we show that the nucleoprotein (NP...
A cell may have hundreds or even thousands of mitochondria depending on its energy demands. Mitochondria are like little factories that specialize in using energy from reactions between oxygen and simple sugars to produce molecules of adenosine triphosphate(ATP)the cell's main energy source. ATP is...
activation states;dsecreted signalling molecules;ealteration of the microbiome;fregulation of cellular quiescence or dormancy;gregulation of cell division;hreactive species in the milieu of each tissue;iresponses to stress;jepigenetic changes in cellular genomes; andktumour cell transition states, such ...
Role of mitochondria in β-cell physiology In order to regulate plasma glucose levels, insulin secretion must be tightly coupled with glucose metabolism. The increase in blood glucose following a meal stimulates the β-cells embedded in the islets of Langerhans to release insulin, which signals the...
metabolism promote nutrient uptake, support increased proliferation and afford resistance to apoptotic cell death. The specific metabolic processes in cancer provide opportunities to selectively target them pharmacologically to improve outcomes for cancer patients. In cancer diagnosis, tumor metabolism can be ...
CellLight® Mitochondria-RFP, BacMam 2.0, provides an easy way to label mitochondria with red fluorescent protein (RFP) in live cells. Simply add the reagent to your cells, incubate overnight, and the cells are ready to image in the morning. ...
play a crucial role in cell fate and aging. Due to the mechanism of replication, telomeres shorten as cells proliferate, which consequently contributes to cellular senescence and mitochondrial dysfunction. Cells are the basic unit of organismal structure and function, and mitochondria are the powerhouse...
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metab